State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology, Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, China.
State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology, Key Laboratory of Bioactive Polysaccharides of Jiangxi Province, Nanchang University, Nanchang 330047, China.
Carbohydr Polym. 2023 Sep 15;316:120986. doi: 10.1016/j.carbpol.2023.120986. Epub 2023 May 16.
Intake of dietary fiber has been proven to have several beneficial effects in maintaining host homeostasis and health. Here, we investigated the effects of different fibers on gut microbiota and related metabolites in rats. Healthy rats were supplemented with guar gum, carrageenan, glucomannan, β-glucan, arabinoxylan, apple pectin, xylan, arabinogalactan, and xanthan gum, and these dietary fibers exhibited commonality and specificity on gut microbiota and related metabolites. The abundance of Phascolarctobacterium, Prevotella, Treponema, Butyricimonas, Bacteroides, and Lactobacillus was selectively increased by different dietary fibers, whereas the abundance of Clostridium perfringens and Bacteroides fragilis were decreased by all of these fibers. Indole-3-lactic acid was significantly increased by β-glucan treatment, indicating the relationship between indole-3-lactic acid and Lactobacillus. Furthermore, Some species from Bacteroides were validated to produce indole-3-lactic acid, indole-3-acetic acid, and kynurenine (such as B. fragilis, B. ovatus, B. thetaiotaomicron, and B. xylanisolvens). These results provide important information on dietary guidelines based on the modification of gut microecology.
膳食纤维的摄入已被证明对维持宿主内环境平衡和健康有多种有益作用。在这里，我们研究了不同纤维对大鼠肠道微生物群和相关代谢物的影响。健康大鼠补充瓜尔胶、卡拉胶、葡甘露聚糖、β-葡聚糖、阿拉伯木聚糖、苹果果胶、木聚糖、阿拉伯半乳聚糖和黄原胶，这些膳食纤维对肠道微生物群和相关代谢物表现出共性和特异性。不同膳食纤维选择性地增加了 Phascolarctobacterium、Prevotella、Treponema、Butyricimonas、Bacteroides 和 Lactobacillus 的丰度，而所有这些纤维都降低了梭状芽孢杆菌和脆弱拟杆菌的丰度。β-葡聚糖处理显著增加了吲哚-3-乳酸的含量，表明了吲哚-3-乳酸与乳酸菌之间的关系。此外，一些来自拟杆菌属的物种被证实可以产生吲哚-3-乳酸、吲哚-3-乙酸和犬尿氨酸（如脆弱拟杆菌、卵形拟杆菌、双歧杆菌和木聚糖分解梭菌）。这些结果为基于肠道微生态修饰的饮食指南提供了重要信息。
