Nourinia Ramin, Rajavi Zhale, Sabbaghi Hamideh, Hassanpour Kiana, Ahmadieh Hamid, Kheiri Bahareh, Rajabpour Mojtaba
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences,Tehran, Iran.
Negah Aref Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Strabismus. 2022 Sep;30(3):132-138. doi: 10.1080/09273972.2022.2097705. Epub 2022 Jul 13.
To determine the optical coherence tomography angiography (OCTA) parameters including foveal avascular zone (FAZ) and vessel density (VD) in the amblyopic eyes compared with the fellow sound eyes and the eyes of the non-amblyopic subjects. In this case-control study, a total of 23 eyes from unilateral amblyopic children were included as cases. The sound eye of the amblyopic children was considered as the internal control and the right eyes of the non-amblyopic children were considered as the external control. All participants underwent image recording with OCTA. In the present study, an equal number of 23 unilateral amblyopic eyes and 23 right eyes of non-amblyopic age- and sex-matched children were included as the cases and controls, respectively. The average age of participants in the case and controls were 9.86 ± 3.12 and 8.5 ± 2.35 years, respectively. Twelve patients (52.2%) in the case group and 14 subjects (60.9%) in the control group were female. Whole vascular density of the macula in superficial capillary plexuses (SCP) was significantly lower in the external controls compared with the other studied groups ( = .026). However, the VD of the deep capillary plexuses (DCP) was significantly greater in the external controls than cases and internal controls (= .029). The average FAZ area was 0.26 ± 0.06 mm in amblyopic eyes that was significantly higher compared with fellow eyes (0.21 ± 0.07 mm; = .022), but it was not different with non-amblyopic eyes (0.22 ± 0.118 mm). Based on our findings, there were no significant difference in the cases of foveal, parafoveal, and perifoveal in both superficial and deep vascular densities among amblyopic and non-amblyopic eyes, whereas deep whole density of the amblyopic eyes showed lower percent compared to non-amblyopic ones that indicates decrease blood supply of the amblyopic eyes in this region. Additionally, FAZ was larger in amblyopic eyes than internal controls.
与对侧健眼和非弱视受试者的眼睛相比，确定弱视眼的光学相干断层扫描血管造影（OCTA）参数，包括黄斑无血管区（FAZ）和血管密度（VD）。在这项病例对照研究中，共纳入23只来自单侧弱视儿童的眼睛作为病例组。弱视儿童的健眼被视为内部对照，非弱视儿童的右眼被视为外部对照。所有参与者均接受了OCTA图像记录。在本研究中，分别纳入了23只单侧弱视眼和23只年龄及性别匹配的非弱视儿童的右眼作为病例组和对照组。病例组和对照组参与者的平均年龄分别为9.86±3.12岁和8.5±2.35岁。病例组中有12名患者（52.2%）为女性，对照组中有14名受试者（60.9%）为女性。与其他研究组相比，外部对照组黄斑浅表毛细血管丛（SCP）的全血管密度显著降低（P = 0.026）。然而，外部对照组深层毛细血管丛（DCP）的VD显著高于病例组和内部对照组（P = 0.029）。弱视眼的平均FAZ面积为0.26±0.06mm，与对侧眼（0.21±0.07mm；P = 0.022）相比显著更高，但与非弱视眼（0.22±0.118mm）无差异。根据我们的研究结果，弱视眼和非弱视眼在浅表和深层血管密度的黄斑中心凹、旁中心凹和周边区域均无显著差异，而弱视眼的深层全密度百分比低于非弱视眼，这表明该区域弱视眼的血液供应减少。此外，弱视眼的FAZ大于内部对照组。
