Hosie J, Hosie G A
Eur J Clin Pharmacol. 1987;32(1):93-5. doi: 10.1007/BF00609965.
We have studied the single dose and steady-state pharmacokinetic of tiaprofenic acid in ten elderly arthritic patients living in the community (5 men and 5 women) taking 200 mg tid for 8 days. The mean area under the plasma concentration-time curves to 8 h (AUC (0-8)) did not alter significantly from day 1 to day 8 (77.25 to 79.61 micrograms X ml-1 X h). The mean terminal phase half-life (t1/2) was 2.05 h and 2.25 h on Days 1 and 8 respectively in patients in whom the calculations were possible (7 patients on Day 1 and 6 patients on Day 8). The median observed time of maximum concentration (tmax) and the mean observed maximum plasma concentration (Cmax) of 100 min and 21.3 micrograms X ml-1 respectively on Day 1 were not significantly different from the values obtained on Day 8 (tmax 120 min; Cmax 20.7 micrograms X ml-1). The kinetic data suggest that there should be no significant accumulation of tiaprofenic acid in elderly ambulant people suffering from arthritis.
我们研究了10名社区老年关节炎患者（5名男性和5名女性）单剂量及稳态下的替诺昔康药代动力学，这些患者每日3次服用200mg，共服用8天。血浆浓度-时间曲线下至8小时的平均面积（AUC(0 - 8)）从第1天到第8天无显著变化（77.25至79.61微克·毫升⁻¹·小时）。在可进行计算的患者中（第1天7名患者，第8天6名患者），平均终末相半衰期（t1/2）在第1天和第8天分别为2.05小时和2.25小时。第1天观察到的最大浓度中位时间（tmax）为100分钟，平均观察到的最大血浆浓度（Cmax）为21.3微克·毫升⁻¹，与第8天获得的值（tmax 120分钟；Cmax 20.7微克·毫升⁻¹）无显著差异。动力学数据表明，替诺昔康在老年活动期关节炎患者中不应有显著蓄积。
