Meurice J
Curr Med Res Opin. 1983;8(5):295-301. doi: 10.1185/03007998309112387.
A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin. Patients received either 600 mg tiaprofenic acid or 100 mg indomethacin daily for 3 months. The results of assessments made every 14 days during the trial showed that tiaprofenic acid was at least as effective as indomethacin in all of the parameters studied and was significantly better in improving pain scores in patients with osteoarthritis of the knee. Fewer gastro-intestinal side-effects were reported in the tiaprofenic acid group. One patient in the indomethacin group had to be withdrawn after 18 days because of severe gastric intolerance.
对60例膝或髋骨关节炎老年患者进行了一项双盲试验，以比较噻洛芬酸与吲哚美辛治疗的疗效和耐受性。患者每日服用600毫克噻洛芬酸或100毫克吲哚美辛，持续3个月。试验期间每14天进行的评估结果显示，在所有研究参数中，噻洛芬酸的疗效至少与吲哚美辛相当，在改善膝骨关节炎患者的疼痛评分方面明显更好。噻洛芬酸组报告的胃肠道副作用较少。吲哚美辛组有1例患者因严重的胃部不耐受在18天后不得不退出试验。
