炎症发作期间，抗坏血酸在眼部发挥保护作用。

A protective role for ascorbic acid during inflammatory episodes in the eye.

作者信息

Williams R N, Paterson C A

出版信息

Exp Eye Res. 1986 Mar;42(3):211-8. doi: 10.1016/0014-4835(86)90055-2.

Abstract

During an experimentally induced inflammatory response in the rabbit eye, the decrease in the ascorbic acid concentration within the aqueous humor corresponded, in large part, to the infiltration of leukocytes into this ocular fluid. Additional in vitro studies demonstrated that activated leukocytes reacted with ascorbic acid, diminishing the concentration of this vitamin in the surrounding medium. We suggest that the very high concentrations of ascorbic acid found in the aqueous humor of a number of species affords extracellular protection for the ocular tissues against oxygen radicals and metabolites released by infiltrating leukocytes during ocular inflammation.

摘要

在兔眼实验性诱导的炎症反应过程中，房水中抗坏血酸浓度的降低在很大程度上与白细胞浸润到这种眼内液体中相对应。额外的体外研究表明，活化的白细胞与抗坏血酸发生反应，降低了周围介质中这种维生素的浓度。我们认为，在许多物种的房水中发现的非常高浓度的抗坏血酸为眼组织提供了细胞外保护，使其免受眼内炎症期间浸润的白细胞释放的氧自由基和代谢产物的伤害。