Ghotbi Jacob, Sahakyan Mushegh, Søreide Kjetil, Fretland Åsmund Avdem, Røsok Bård, Tholfsen Tore, Waage Anne, Edwin Bjørn, Labori Knut Jørgen, Yaqub Sheraz, Kleive Dyre
Department of Hepato-Pancreato-Biliary Surgery, Oslo University Hospital, Oslo, Norway.
The Intervention Center, Rikshospitalet, Oslo University Hospital, Oslo, Norway.
Oncol Ther. 2022 Dec;10(2):301-315. doi: 10.1007/s40487-022-00203-6. Epub 2022 Jul 12.
Minimally invasive pancreatoduodenectomy has gained popularity throughout the last decade. For laparoscopic pancreatoduodenectomy, some high-level evidence exists, but with conflicting results. There are currently no published randomized controlled trials comparing robotic and open pancreatoduodenectomy. Comparative long-term data for patients with pancreatic ductal adenocarcinoma is lacking to date. Based on the existing evidence, current observed benefits of minimally invasive pancreatoduodenectomy over open pancreatoduodenectomy seem scarce, but retrospective data indicate the safety of these procedures in selected patients. As familiarity with the robotic platform increases, studies have shown an expansion in indications, also including patients with vascular involvement and even indicating favorable results in patients with obesity and high-risk morphometric features. Several ongoing randomized controlled trials aim to investigate potential differences in short- and long-term outcomes between minimally invasive and open pancreatoduodenectomy. Their results are much awaited.
在过去十年中，微创胰十二指肠切除术越来越受欢迎。对于腹腔镜胰十二指肠切除术，存在一些高级别证据，但结果相互矛盾。目前尚无比较机器人辅助和开放胰十二指肠切除术的随机对照试验发表。迄今为止，缺乏胰腺导管腺癌患者的长期对比数据。基于现有证据，目前观察到的微创胰十二指肠切除术相对于开放胰十二指肠切除术的益处似乎很少，但回顾性数据表明这些手术在特定患者中的安全性。随着对机器人平台的熟悉程度增加，研究表明其适应症有所扩大，还包括血管受累患者，甚至表明肥胖和具有高风险形态特征的患者也能取得良好结果。几项正在进行的随机对照试验旨在研究微创和开放胰十二指肠切除术在短期和长期结果方面的潜在差异。人们热切期待它们的结果。
