Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Division of Population Sciences, Department of Medical Oncology, Dana-Farber Cancer Institute, 375 Longwood Avenue, MB, Boston, USA.
Curr Oncol Rep. 2022 Nov;24(11):1593-1605. doi: 10.1007/s11912-022-01313-0. Epub 2022 Jul 13.
Sedentary behaviors (SB) after cancer diagnosis are associated with poor prognosis for certain cancers, and cancer patients and survivors report high levels of SB. Reducing SB may be a feasible and effective intervention strategy to improve outcomes. This systematic review aims to identify and evaluate the literature on interventions to reduce SB in cancer patients and survivors.
Studies were identified via database searches in December 2020. Two authors evaluated study eligibility. Data were extracted and checked, and risk of bias was assessed by the study team. Of 1401 records identified, nine studies involving 394 cancer patients or survivors were included in this review. Six were randomized trials, three were non-randomized intervention studies, and almost all (n = 8) focused on feasibility with small sample sizes. All studies were conducted within the previous 5 years in Canada, Australia, USA, and South Korea. Cancer types studied were breast (n = 3), prostate (n = 2), colorectal or peritoneal (n = 1), and mixed types (n = 3). Intervention duration of 12 weeks was most common (n = 7). Five studies had multiple intervention components, and six studies included wearable devices to measure and/or prompt behavior change. There was an overall trend where intervention groups reduced SB vs. control groups, often coupled with an increase in moderate-to-vigorous physical activity. This review suggests that there is some promise for intervention strategies to reduce SB in cancer patients and survivors. There is a need for more high-quality randomized controlled trials to understand how to best decrease SB in cancer patients and survivors.
目的综述：癌症诊断后的久坐行为（SB）与某些癌症的预后不良有关，癌症患者和幸存者报告的 SB 水平较高。减少 SB 可能是改善结局的一种可行且有效的干预策略。本系统综述旨在确定和评估旨在减少癌症患者和幸存者 SB 的干预措施的文献。
最近发现：2020 年 12 月通过数据库搜索确定了研究。两位作者评估了研究的合格性。研究小组提取和检查了数据，并评估了偏倚风险。在确定的 1401 条记录中，有 9 项研究涉及 394 名癌症患者或幸存者，包括在本次综述中。其中 6 项为随机试验，3 项为非随机干预研究，几乎所有研究（n=8）都关注可行性，样本量较小。所有研究均在过去 5 年内，在加拿大、澳大利亚、美国和韩国进行。研究的癌症类型包括乳腺癌（n=3）、前列腺癌（n=2）、结直肠癌或腹膜癌（n=1）和混合类型（n=3）。最常见的干预持续时间为 12 周（n=7）。有 5 项研究有多个干预组成部分，6 项研究包括可穿戴设备来测量和/或提示行为改变。干预组与对照组相比，SB 呈总体下降趋势，通常伴随着中等至剧烈体力活动的增加。本综述表明，干预策略在减少癌症患者和幸存者的 SB 方面有一定的前景。需要更多高质量的随机对照试验来了解如何最好地减少癌症患者和幸存者的 SB。
