醉茄素A的微生物学和化学脱氢作用。
Microbiological and chemical dehydrogenation of withaferin A.
作者信息
Fuska J, Proska B, Williamson J, Rosazza J P
出版信息
Folia Microbiol (Praha). 1987;32(2):112-5. doi: 10.1007/BF02883237.
PMID:3583136
Abstract
Arthrobacter simplex dehydrogenated withaferin A to 4-dehydrowithaferin A but it was not able to dehydrogenate this substrate in position 27. 27-Dehydrowithaferin A was prepared chemically using pyridinium chlorochromate. Whereas 4-dehydrowithaferin A surpassed in its effect on leukemic (388 cells the original compound and all its derivates synthesized so far, 27-dehydrowithaferin A was biologically inactive.
摘要
简单节杆菌将威他菌素A脱氢生成4-脱氢威他菌素A，但无法在27位使该底物脱氢。27-脱氢威他菌素A是使用氯铬酸吡啶鎓通过化学方法制备的。尽管4-脱氢威他菌素A对白血病（388细胞）的作用超过了原始化合物及其迄今为止合成的所有衍生物，但27-脱氢威他菌素A没有生物活性。
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