Interdisciplinary Department of Medicine, University of Bari School of Medicine, Piazza G. Cesare, 11, 70124, Bari, Italy.
Plant Foods Hum Nutr. 2022 Sep;77(3):481-483. doi: 10.1007/s11130-022-00986-z. Epub 2022 Jul 14.
In the past few years, evidence has supported the role of plants as a valuable tool for the development of promising therapeutic support options for many diseases, including cancer. We recently discovered that the edible wild plant Crithmum maritimum L. effectively inhibits the growth of hepatocellular carcinoma (HCC) cells and we provide insights into the biological mechanisms involved. Here, we aimed to characterize the effect of ethyl acetate extract of Crithmum maritimum on the bioenergetic phenotype of HCC cells and if this is associated with the anti-tumour effect we previously described. Results show that Crithmum maritimum significantly increases cellular respiration and reduces lactic fermentation in HCC cells, and that this reduction of the fermentative glycolytic phenotype is linked to inhibition of HCC growth. These data provide new preclinical evidence supporting the role of Crithmum maritimum L. as a nutraceutical option to expand the therapeutic opportunities in the management of HCC.
在过去的几年中，有证据表明植物可以作为一种有价值的工具，用于开发许多疾病（包括癌症）的有前途的治疗支持选择。我们最近发现，可食用的野生植物海蓬子能有效抑制肝癌（HCC）细胞的生长，并深入了解了相关的生物学机制。在这里，我们旨在描述海蓬子乙酸乙酯提取物对 HCC 细胞生物能量表型的影响，以及这是否与我们之前描述的抗肿瘤作用有关。结果表明，海蓬子能显著增加 HCC 细胞的细胞呼吸，并降低乳酸发酵，而这种发酵型糖酵解表型的减少与 HCC 生长的抑制有关。这些数据为海蓬子作为一种营养保健品的作用提供了新的临床前证据，以扩大 HCC 管理中治疗机会。
