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characterization of potentially health-promoting constituents in sea fennel () cultivated in the Conero Natural Park (Marche region, Central Italy).

Characterization of potentially health-promoting constituents in sea fennel () cultivated in the Conero Natural Park (Marche region, Central Italy).

机构信息

Dipartimento di Scienze Agrarie, Alimentari ed Ambientali, Università Politecnica delle Marche, Ancona, Italy.

Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.

出版信息

Pharm Biol. 2023 Dec;61(1):1030-1040. doi: 10.1080/13880209.2023.2224820.

DOI:10.1080/13880209.2023.2224820
PMID:37409739
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10327526/
Abstract

CONTEXT

Sea fennel ( L. [Apiaceae]) is an aromatic herb rich in bioactive molecules, such as polyphenols, with potential positive effects on human health.

OBJECTIVE

This study aimed at the characterization of sea fennel secondary metabolites, focusing on the phenolic fraction.

MATERIALS AND METHODS

Samples of whole sprouts, sole leaves and sole stems were subjected to accelerated solvent extraction with methanol, and the resulting extracts were analyzed by high‑performance thin‑layer chromatography, high-performance liquid chromatography, and liquid chromatography coupled with diode array detection and high-resolution mass spectrometry (LC-DAD-HRMS).

RESULTS

HPTLC and HPLC analyses of sea fennel extracts showed similar chromatographic profiles among the tested samples, and the prevalence of chlorogenic acid within the phenolic fraction was verified. Ten hydroxycinnamic acids, including neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid, isochlorogenic acid B, isochlorogenic acid A and isochlorogenic acid C, 11 flavonoid glycosides, e.g., rutin, hyperoside, isoquercitrin, two triterpene saponins and two hydroxylated fatty acids, were detected and annotated liquid chromatography coupled with diode array detection and high-resolution mass spectrometry.

DISCUSSION AND CONCLUSIONS

The use of accelerated solvent extraction and LC-DAD-HRMS for the characterization of sea fennel secondary metabolites allowed the annotation of seven compounds newly detected in sea fennel, including triterpene saponins and hydroxylated fatty acids.

摘要

背景

海茴香（L. [伞形科]）是一种富含生物活性分子的芳香草本植物，如多酚，对人类健康可能有积极影响。

目的

本研究旨在对海茴香次生代谢产物进行特征分析，重点研究酚类成分。

材料与方法

对整株幼苗、单叶和单茎样品进行甲醇加速溶剂萃取，用高效薄层色谱法、高效液相色谱法和液相色谱-二极管阵列检测-高分辨率质谱联用（LC-DAD-HRMS）对提取物进行分析。

结果

海茴香提取物的 HPTLC 和 HPLC 分析显示，测试样品之间的色谱图谱相似，证实了酚类成分中绿原酸的存在。检测并注释了 10 种羟基肉桂酸，包括新绿原酸、绿原酸、隐绿原酸、异绿原酸 B、异绿原酸 A 和异绿原酸 C，11 种黄酮苷，如芦丁、金丝桃苷、异槲皮苷、两种三萜皂苷和两种羟基脂肪酸，利用 LC-DAD-HRMS 对海茴香次生代谢产物进行了特征分析，鉴定出了 7 种新化合物，包括三萜皂苷和羟基脂肪酸。

讨论与结论

采用加速溶剂萃取和 LC-DAD-HRMS 对海茴香次生代谢产物进行特征分析，可以鉴定出 7 种新化合物，包括三萜皂苷和羟基脂肪酸。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c89e/10327526/dee488c57c94/IPHB_A_2224820_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c89e/10327526/6dace4a2302f/IPHB_A_2224820_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c89e/10327526/8a0e6d4b9f38/IPHB_A_2224820_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c89e/10327526/dee488c57c94/IPHB_A_2224820_F0003_B.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c89e/10327526/6dace4a2302f/IPHB_A_2224820_F0001_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c89e/10327526/8a0e6d4b9f38/IPHB_A_2224820_F0002_C.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c89e/10327526/dee488c57c94/IPHB_A_2224820_F0003_B.jpg

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