• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

热处理对大鼠骨骼肌损伤后肌肉恢复的影响：组织学和免疫组织化学研究

Influence of Heat Treatment on Muscle Recovery after Skeletal Muscle Injury in Rats: Histological and Immunohistochemical Studies.

作者信息

El-Sheikh Amal Ahmed, El-Kordy Eman Ali, Issa Sara Alaa

机构信息

Department of Anatomy, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Department of Anatomy, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.

出版信息

J Microsc Ultrastruct. 2021 Jun 3;10(2):63-71. doi: 10.4103/jmau.jmau_85_20. eCollection 2022 Apr-Jun.

DOI:10.4103/jmau.jmau_85_20
PMID:35832314
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9272698/
Abstract

BACKGROUND

Muscle injuries represent a great part of athletic injuries. The repairing of skeletal muscle after injury is highly influenced by its regenerative response that may be affected by thermotherapy.

AIM

This research examined the consequence of heat therapy on muscle recovery after skeletal muscle injury in rats.

MATERIALS AND METHODS

Forty-five male adult albino rats were classified into three groups: control, cardiotoxin-injected without heat (nonheating group), and cardiotoxin-injected with heat (heating group). Muscle injury was caused by the injection of cardiotoxin intramuscularly into the tibialis anterior muscles. Heating treatment (40°C for 20 min) was started immediately after the injury. Subsequent observations were performed at day 1, 3, and 7 after injury, including histological imaging and vimentin immunostaining expression.

RESULTS

In the heating group, the regenerating myotubes, having two or more central nuclei, first looked at 3 days after muscle injury, while in the nonheating group, the regenerating fibers were first observed at 7 days after muscle injury. Immunohistochemically, the vimentin reactions were absent in control muscle fibers but were identified in regenerating muscle fiber of the heating group earlier than in the nonheating group.

CONCLUSION

Starting of heat treatment immediately after muscle injury promoted the regeneration of muscle fibers.

摘要

背景

肌肉损伤在运动损伤中占很大比例。损伤后骨骼肌的修复受到其再生反应的高度影响，而热疗可能会影响这种再生反应。

目的

本研究探讨热疗对大鼠骨骼肌损伤后肌肉恢复的影响。

材料与方法

45只成年雄性白化大鼠分为三组：对照组、注射心脏毒素但无热疗组（非热疗组）和注射心脏毒素并进行热疗组（热疗组）。通过向胫骨前肌内注射心脏毒素造成肌肉损伤。损伤后立即开始热疗（40°C，持续20分钟）。在损伤后第1天、第3天和第7天进行后续观察，包括组织学成像和波形蛋白免疫染色表达。

结果

在热疗组中，有两个或更多中央核的再生肌管在肌肉损伤后3天首次出现，而在非热疗组中，再生纤维在肌肉损伤后7天首次观察到。免疫组织化学分析显示，对照组肌肉纤维中无波形蛋白反应，但热疗组再生肌肉纤维中的波形蛋白反应比非热疗组出现得更早。

结论

肌肉损伤后立即开始热疗可促进肌肉纤维再生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/50c7631a7bf1/JMAU-10-63-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/c7be5efba039/JMAU-10-63-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/653004b09928/JMAU-10-63-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/46e3f785f52b/JMAU-10-63-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/50facf8ca6f2/JMAU-10-63-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/df9cc79387f0/JMAU-10-63-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/a1ac40fcb63c/JMAU-10-63-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/cec881c19abf/JMAU-10-63-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/09b9894a3812/JMAU-10-63-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/5790750cfeb6/JMAU-10-63-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/239d8472ef00/JMAU-10-63-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/2cbc6617c962/JMAU-10-63-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/9e946c675aa4/JMAU-10-63-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/a9d007692382/JMAU-10-63-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/7312a190a262/JMAU-10-63-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/52aafb4690af/JMAU-10-63-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/e28ccf0abaf5/JMAU-10-63-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/5ddbb9da7d55/JMAU-10-63-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/c949522cf317/JMAU-10-63-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/fc4f7ec2cc87/JMAU-10-63-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/83b36144bfc2/JMAU-10-63-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/02908c7ce682/JMAU-10-63-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/50c7631a7bf1/JMAU-10-63-g022.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/c7be5efba039/JMAU-10-63-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/653004b09928/JMAU-10-63-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/46e3f785f52b/JMAU-10-63-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/50facf8ca6f2/JMAU-10-63-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/df9cc79387f0/JMAU-10-63-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/a1ac40fcb63c/JMAU-10-63-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/cec881c19abf/JMAU-10-63-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/09b9894a3812/JMAU-10-63-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/5790750cfeb6/JMAU-10-63-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/239d8472ef00/JMAU-10-63-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/2cbc6617c962/JMAU-10-63-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/9e946c675aa4/JMAU-10-63-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/a9d007692382/JMAU-10-63-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/7312a190a262/JMAU-10-63-g014.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/52aafb4690af/JMAU-10-63-g015.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/e28ccf0abaf5/JMAU-10-63-g016.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/5ddbb9da7d55/JMAU-10-63-g017.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/c949522cf317/JMAU-10-63-g018.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/fc4f7ec2cc87/JMAU-10-63-g019.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/83b36144bfc2/JMAU-10-63-g020.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/02908c7ce682/JMAU-10-63-g021.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd65/9272698/50c7631a7bf1/JMAU-10-63-g022.jpg

相似文献

1
Influence of Heat Treatment on Muscle Recovery after Skeletal Muscle Injury in Rats: Histological and Immunohistochemical Studies.热处理对大鼠骨骼肌损伤后肌肉恢复的影响：组织学和免疫组织化学研究
J Microsc Ultrastruct. 2021 Jun 3;10(2):63-71. doi: 10.4103/jmau.jmau_85_20. eCollection 2022 Apr-Jun.
2
Heat stress facilitates the regeneration of injured skeletal muscle in rats.热应激促进大鼠损伤骨骼肌的再生。
J Orthop Sci. 2007 Jan;12(1):74-82. doi: 10.1007/s00776-006-1083-0. Epub 2007 Jan 31.
3
Impact of different temperature stimuli on the expression of myosin heavy chain isoforms during recovery from bupivacaine-induced muscle injury in rats.不同温度刺激对布比卡因诱导的大鼠肌肉损伤后恢复过程中肌球蛋白重链同工型表达的影响。
J Appl Physiol (1985). 2019 Jul 1;127(1):178-189. doi: 10.1152/japplphysiol.00930.2018. Epub 2019 May 23.
4
The expression of dystrophin and alpha1-syntrophin during skeletal muscle regeneration.肌营养不良蛋白和α1-肌聚糖蛋白在骨骼肌再生过程中的表达
J Muscle Res Cell Motil. 2001;22(2):185-91. doi: 10.1023/a:1010553104341.
5
Microcurrent electrical neuromuscular stimulation facilitates regeneration of injured skeletal muscle in mice.微电流电神经肌肉刺激促进小鼠受伤骨骼肌的再生。
J Sports Sci Med. 2015 May 8;14(2):297-303. eCollection 2015 Jun.
6
Enhancement of satellite cell differentiation and functional recovery in injured skeletal muscle by hyperbaric oxygen treatment.高压氧处理增强损伤骨骼肌卫星细胞的分化和功能恢复。
J Appl Physiol (1985). 2014 Jan 15;116(2):149-55. doi: 10.1152/japplphysiol.00235.2013. Epub 2013 Dec 12.
7
Expression of nestin, desmin and vimentin in intact and regenerating muscle spindles of rat hind limb skeletal muscles.巢蛋白、结蛋白和波形蛋白在大鼠后肢骨骼肌完整及再生肌梭中的表达
Histochem Cell Biol. 2009 Feb;131(2):197-206. doi: 10.1007/s00418-008-0523-7. Epub 2008 Oct 22.
8
Extracorporeal Shock Wave Therapy Accelerates Regeneration After Acute Skeletal Muscle Injury.体外冲击波疗法可加速急性骨骼肌损伤后的再生。
Am J Sports Med. 2017 Mar;45(3):676-684. doi: 10.1177/0363546516668622. Epub 2016 Oct 13.
9
Early ultrastructural events of skeletal muscle damage following cardiotoxin-induced injury and glycerol-induced injury.心脏毒素诱导损伤和甘油诱导损伤后骨骼肌损伤的早期超微结构变化
Micron. 2016 Dec;91:29-40. doi: 10.1016/j.micron.2016.09.009. Epub 2016 Sep 28.
10
Angiopoietin-1 enhances skeletal muscle regeneration in mice.血管生成素-1可促进小鼠骨骼肌再生。
Am J Physiol Regul Integr Comp Physiol. 2015 Apr 1;308(7):R576-89. doi: 10.1152/ajpregu.00267.2014. Epub 2015 Jan 21.

引用本文的文献

1
Influence of contrast compression therapy and water immersion contrast therapy on biomechanical parameters of the forearm muscles in martial arts athletes.对比压缩疗法和水浸对比疗法对武术运动员前臂肌肉生物力学参数的影响。
Front Physiol. 2025 Apr 10;16:1494762. doi: 10.3389/fphys.2025.1494762. eCollection 2025.
2
Effects of thermal interventions on skeletal muscle adaptations and regeneration: perspectives on epigenetics: a narrative review.热干预对骨骼肌适应与再生的影响：表观遗传学视角：一篇叙述性综述
Eur J Appl Physiol. 2025 Feb;125(2):277-301. doi: 10.1007/s00421-024-05642-9. Epub 2024 Nov 28.
3
Development of three-dimensional primary human myospheres as culture model of skeletal muscle cells for metabolic studies.

本文引用的文献

1
Changes in Muscle Contractile Properties after Cold- or Warm-Water Immersion Using Tensiomyography: A Cross-Over Randomised Trial.冷/温水浸浴后使用张力描记术评估肌肉收缩性能的变化：一项交叉随机试验。
Sensors (Basel). 2020 Jun 4;20(11):3193. doi: 10.3390/s20113193.
2
Distribution and Expression of Vimentin and Desmin in Broiler Affected by the Growth-Related Muscular Abnormalities.波形蛋白和结蛋白在受生长相关肌肉异常影响的肉鸡中的分布与表达
Front Physiol. 2020 Jan 17;10:1581. doi: 10.3389/fphys.2019.01581. eCollection 2019.
3
Expression of E-cadherin, vimentin and β-catenin in ameloblastoma and association with clinicopathological characteristics of ameloblastoma.
三维原代人肌球作为骨骼肌细胞代谢研究培养模型的开发。
Front Bioeng Biotechnol. 2023 Mar 23;11:1130693. doi: 10.3389/fbioe.2023.1130693. eCollection 2023.
E-钙黏蛋白、波形蛋白和β-连环蛋白在成釉细胞瘤中的表达及其与成釉细胞瘤临床病理特征的关系
Int J Clin Exp Pathol. 2018 Jan 1;11(1):199-207. eCollection 2018.
4
Cellular elements in the developing caecum of Japanese quail (Coturnix coturnix japonica): morphological, morphometrical, immunohistochemical and electron-microscopic studies.日本鹌鹑盲肠发育过程中的细胞成分：形态学、形态计量学、免疫组织化学和电子显微镜研究。
Sci Rep. 2019 Nov 7;9(1):16241. doi: 10.1038/s41598-019-52335-x.
5
Impact of different temperature stimuli on the expression of myosin heavy chain isoforms during recovery from bupivacaine-induced muscle injury in rats.不同温度刺激对布比卡因诱导的大鼠肌肉损伤后恢复过程中肌球蛋白重链同工型表达的影响。
J Appl Physiol (1985). 2019 Jul 1;127(1):178-189. doi: 10.1152/japplphysiol.00930.2018. Epub 2019 May 23.
6
YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells.YY1 通过调控卫星细胞的代谢重编程来调节骨骼肌再生。
EMBO J. 2019 May 15;38(10). doi: 10.15252/embj.201899727. Epub 2019 Apr 12.
7
ZEB1 protects skeletal muscle from damage and is required for its regeneration.ZEB1 可保护骨骼肌免受损伤，并对其再生具有重要作用。
Nat Commun. 2019 Mar 25;10(1):1364. doi: 10.1038/s41467-019-08983-8.
8
Muscle Fiber Splitting Is a Physiological Response to Extreme Loading in Animals.肌肉纤维分裂是动物对极端负荷的生理反应。
Exerc Sport Sci Rev. 2019 Apr;47(2):108-115. doi: 10.1249/JES.0000000000000181.
9
Muscle Satellite Cell Cross-Talk with a Vascular Niche Maintains Quiescence via VEGF and Notch Signaling.肌肉卫星细胞与血管龛的相互作用通过 VEGF 和 Notch 信号维持静息状态。
Cell Stem Cell. 2018 Oct 4;23(4):530-543.e9. doi: 10.1016/j.stem.2018.09.007.
10
Cytoplasmic Intermediate Filaments in Cell Biology.细胞质中间丝在细胞生物学中的作用
Annu Rev Cell Dev Biol. 2018 Oct 6;34:1-28. doi: 10.1146/annurev-cellbio-100617-062534. Epub 2018 Jul 30.