Center of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Department of Pathology, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Contrast Media Mol Imaging. 2022 Jun 25;2022:7808726. doi: 10.1155/2022/7808726. eCollection 2022.
The present study is aimed at exploring whether rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene confer risk for ovarian cancer.
A total of 80 patients with ovarian cancer were selected from the first affiliated hospital of Soochow University in Jiangsu Province from January 2016 to June 2021, including 48 cases that were premenopausal and 32 cases that were menopausal. 130 healthy women who participated in normal physical examinations during the same period were selected as the control group. The rs3213172, rs3213173, and rs3213176 polymorphisms of the E2F1 gene were detected by the fluorescent probe method.
For rs3213173 and rs3213176 loci, there were no statistical significances in genotype distribution frequency between the ovarian cancer group and the control group ( > 0.05). For rs3213172 loci, a significant difference was observed in CT genotype between the ovarian cancer group and the control group (=0.024).
E2F1 gene rs3213173 and rs3213176 polymorphisms confer no risk to ovarian cancer risk. The CT genotype of E2F1 gene rs3213172 polymorphism is associated with an increased risk of ovarian cancer, and E2F1 gene rs3213172 polymorphism may be a novel marker for the risk prediction of ovarian cancer.
本研究旨在探讨 E2F1 基因 rs3213172、rs3213173 和 rs3213176 多态性是否与卵巢癌发病风险相关。
选取 2016 年 1 月至 2021 年 6 月在苏州大学附属第一医院就诊的 80 例卵巢癌患者为病例组，其中 48 例为绝经前患者，32 例为绝经后患者；另选取同期于该院体检的 130 例健康女性作为对照组。采用荧光探针法检测 E2F1 基因 rs3213172、rs3213173 和 rs3213176 多态性。
rs3213173 和 rs3213176 位点在卵巢癌组与对照组间的基因型分布频率比较，差异均无统计学意义（>0.05）；rs3213172 位点在卵巢癌组与对照组间 CT 基因型分布频率比较，差异有统计学意义（=0.024）。
E2F1 基因 rs3213173 和 rs3213176 多态性与卵巢癌发病风险无关，E2F1 基因 rs3213172 多态性 CT 基因型与卵巢癌发病风险相关，E2F1 基因 rs3213172 多态性可能是卵巢癌发病风险的新型标志物。
