Department of Paediatrics, Clinical Center of the University of Pécs, Medical School, University of Pécs, Pécs, Hungary.
Institute of Geobotany/Plant Ecology, Martin-Luther-University, Halle (Saale), Germany.
Crit Rev Food Sci Nutr. 2023 Nov;63(33):12018-12035. doi: 10.1080/10408398.2022.2098246. Epub 2022 Jul 14.
Inulin-type fructans are considered to stimulate the growth of beneficial microorganisms, like in the gut and support health. However, both the fructan source and chemical structure may modify these effects. A systematic review was conducted to assess the effects of chicory-derived inulin-type fructans consumed either in specific foods or as dietary supplements on abundance of in the gut and on health-related outcomes. Three electronic databases and two clinical trial registries were systematically searched until January 2021. Two authors independently selected randomized controlled trials that investigated with a protocol of minimum seven days supplementation the effect of chicory-derived inulin-type fructans on abundance in any population. Meta-analyses with random-effects model were conducted on abundance and bowel function parameters. We evaluated risk of bias using Cochrane RoB tool. Chicory-derived inulin-type fructans at a dose of 3-20 g/day significantly increased abundance in participants with an age range from 0 to 83 years (standardized mean difference: 0.83, 95% CI: 0.58-1.08; < 0.01; 50 studies; 2525 participants). Significant bifidogenic effects were observed in healthy individuals and in populations with health impairments, except gastrointestinal disorders. Significant beneficial effects on bowel function parameters were observed in healthy subjects. Chicory-derived inulin-type fructans may have significant bifidogenic effects and may beneficially influence bowel function in healthy individuals. PROSPERO registration number CRD42020162892.
菊苣型果聚糖被认为可以刺激有益微生物的生长，例如肠道中的双歧杆菌，从而支持健康。然而，果聚糖的来源和化学结构都可能改变这些效果。本系统评价旨在评估食用菊苣来源的特定食物或膳食补充剂中的菊苣型果聚糖对肠道中双歧杆菌丰度和与健康相关的结果的影响。系统检索了三个电子数据库和两个临床试验注册处，检索截止日期为 2021 年 1 月。两位作者独立选择了随机对照试验，这些试验采用至少七天的补充方案，研究了菊苣来源的菊苣型果聚糖对任何人群中双歧杆菌丰度的影响。采用随机效应模型对双歧杆菌丰度和肠道功能参数进行了荟萃分析。我们使用 Cochrane RoB 工具评估了偏倚风险。菊苣来源的果聚糖，剂量为 3-20g/天，可显著增加 0-83 岁人群的双歧杆菌丰度（标准化均数差：0.83，95%CI：0.58-1.08； <0.01；50 项研究；2525 名参与者）。在健康个体和有健康损害的人群中，除了胃肠道疾病外，均观察到显著的双歧杆菌增殖作用。在健康受试者中，还观察到对肠道功能参数的有益影响。菊苣来源的果聚糖可能具有显著的双歧杆菌增殖作用，并可能对健康个体的肠道功能产生有益影响。PROSPERO 注册号 CRD42020162892。
