Clegg M S, Ferrell F, Keen C L
Hypertension. 1987 Jun;9(6):624-8. doi: 10.1161/01.hyp.9.6.624.
It has been suggested that one risk factor in the development of hypertension and vascular disease may be abnormal copper and zinc metabolism. In the current study we tested the hypothesis that hypertension itself may result in alterations in the metabolism of these essential elements. Dahl salt-sensitive rats were fed diets containing 0.4 or 8.0% NaCl for 32 days. At the conclusion of the study, blood pressure was significantly higher in the rats fed a high NaCl diet than in controls. Liver, kidney, and heart copper concentrations were significantly lower in the rats fed a high NaCl diet compared with controls, while plasma copper levels were higher. In contrast, tissue zinc levels were higher in the rats fed a high NaCl diet than in controls, while plasma zinc levels were lower. It is hypothesized that alterations in copper and zinc metabolism may be one factor underlying tissue damage in these animals.
有人提出，高血压和血管疾病发展的一个风险因素可能是铜和锌代谢异常。在当前的研究中，我们检验了这样一个假设，即高血压本身可能导致这些必需元素代谢的改变。给Dahl盐敏感大鼠喂食含0.4%或8.0%氯化钠的饮食32天。在研究结束时，喂食高氯化钠饮食的大鼠血压显著高于对照组。与对照组相比，喂食高氯化钠饮食的大鼠肝脏、肾脏和心脏中的铜浓度显著降低，而血浆铜水平则较高。相比之下，喂食高氯化钠饮食的大鼠组织锌水平高于对照组，而血浆锌水平则较低。据推测，铜和锌代谢的改变可能是这些动物组织损伤的一个潜在因素。
