Department of Cardiology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, 401120, China.
Department of Stomatology, The Seventh Affiliated Hospital Sun Yat-Sen University, Shenzhen, 518000, China.
BMC Cardiovasc Disord. 2021 Jan 28;21(1):57. doi: 10.1186/s12872-021-01880-3.
Copper is an essential trace metal with potential interest for cardiovascular effects. Few studies have explored the association between copper and blood pressure in children and adolescents.
We conducted a cross-sectional analysis of 1242 children and adolescents aged 8-17 years who participated in the 2011 to 2016 National Health and Nutrition Examination Survey. Using 2017 American Academy of Pediatrics guidelines, elevated blood pressure (EBP) was defined as a mean systolic and/or diastolic blood pressure (BP) ≥ 90th percentile for sex, age, and height for children aged 1-12 years and systolic BP ≥ 120 mmHg or diastolic BP ≥ 80 mmHg for adolescent age 13-17 years. Mean serum copper was 114.17 μg/dL.
After multiple adjustments, dose-response analyses revealed that EBP was associated with progressively higher serum copper concentrations in a nonlinear trend. In comparison with the lowest quartile of serum copper concentrations, the adjusted odds of EBP for the highest quartile was 5.26 (95% confidence interval, 2.76-10.03).
Our results suggested that high serum copper concentrations were significantly associated with EBP in US children and adolescents.
铜是一种必需的微量元素，对心血管系统可能具有潜在影响。少数研究探讨了铜与儿童和青少年血压之间的关系。
我们对 2011 年至 2016 年参加全国健康和营养检查调查的 1242 名 8-17 岁儿童和青少年进行了横断面分析。根据 2017 年美国儿科学会指南，高血压（EBP）定义为年龄在 1-12 岁的儿童性别、年龄和身高的收缩压和/或舒张压均值≥第 90 百分位，13-17 岁青少年的收缩压≥120mmHg 或舒张压≥80mmHg。平均血清铜浓度为 114.17μg/dL。
经过多次调整，剂量反应分析显示，EBP 与血清铜浓度呈非线性趋势的逐渐升高相关。与血清铜浓度最低四分位相比，血清铜浓度最高四分位的 EBP 调整比值比为 5.26（95%置信区间，2.76-10.03）。
我们的结果表明，美国儿童和青少年的高血清铜浓度与 EBP 显著相关。
