评估唾液α-淀粉酶和黏蛋白-4 在种植体周围黏膜炎非手术治疗前后的变化。

Assessment of salivary alpha amylase and mucin-4 before and after non-surgical treatment of peri-implant mucositis.

机构信息

Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, 11451, Saudi Arabia.

Department of General Dental Practice, Kuwait University, P. O. Box 24923, 13110, Safat, Kuwait.

出版信息

Int J Implant Dent. 2022 Jul 14;8(1):30. doi: 10.1186/s40729-022-00429-z.

DOI:10.1186/s40729-022-00429-z

PMID:35834021

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9283593/

Abstract

BACKGROUND

The present study was based on the null hypothesis that there is no difference in clinicoradiographic parameters and whole salivary alpha amylase (AA) and mucin-4 levels before and after non-surgical mechanical debridement (NSMD) of patients with peri-implant mucositis (PM). The aim was to assess whole salivary AA and mucin-4 levels before and after treatment of PM.

METHODS

Patients with PM (Group-1) and individuals without peri-implant diseases (Group-2) were included. Demographic data was collected and peri-implant modified plaque and bleeding indices (mPI and mBI, respectively), probing depth (PD) and crestal bone loss were measured at baseline. Levels of AA and mucin-4 were assessed in unstimulated whole saliva samples. All patients underwent full-mouth non-surgical periodontal therapy (NSPT) and NSMD; and clinical parameters and salivary biomarkers were re-assessed after 3 months. Level of significance was set at P < 0.01.

RESULTS

Twenty-six and 32 individuals were included in groups 1 and 2, respectively. None of the participants had periodontitis. At baseline clinical periodontal parameters (PI [P < 0.001], GI [P < 0.001], clinical AL [P < 0.001] and PD [P < 0.001]) were significantly high in Group-1 than Group-2. At 3-month follow-up, there was a statistically significant reduction in clinical periodontal and peri-implant parameters (PI [P < 0.01], GI [P < 0.01], and PD [P < 0.01]) in Group-1 compared with their baseline values. At baseline, salivary AA levels were significantly high in Group-1 than Group-2 (P < 0.01). At 3-month follow-up, there was no significant difference in whole salivary AA levels among patients in groups 1 and 2.

CONCLUSIONS

The AA and mucin-4 levels are potential biomarkers for evaluation of peri-implant diseases including PM. Mechanical instrumentation continues to be the most predictable treatment option for the management of peri-implant diseases.

摘要

背景

本研究基于以下假设，即接受非手术机械清创术（NSMD）治疗的种植体周围黏膜炎（PM）患者的临床影像学参数以及全唾液α-淀粉酶（AA）和黏蛋白-4（mucin-4）水平在治疗前后没有差异。本研究的目的是评估 PM 治疗前后的全唾液 AA 和 mucin-4 水平。

方法

纳入 PM 患者（组 1）和无种植体周围疾病的个体（组 2）。收集人口统计学数据，在基线时测量种植体周围改良菌斑和出血指数（mPI 和 mBI）、探诊深度（PD）和牙槽骨丧失情况。评估未刺激全唾液样本中的 AA 和 mucin-4 水平。所有患者均接受全口非手术牙周治疗（NSPT）和 NSMD；在 3 个月后重新评估临床参数和唾液生物标志物。显著性水平设置为 P<0.01。

结果

分别有 26 人和 32 人纳入组 1 和组 2。所有参与者均无牙周炎。在基线时，组 1 的临床牙周参数（PI [P<0.001]、GI [P<0.001]、临床附着水平 [P<0.001] 和 PD [P<0.001]）显著高于组 2。在 3 个月的随访中，与基线值相比，组 1 的临床牙周和种植体周围参数（PI [P<0.01]、GI [P<0.01] 和 PD [P<0.01]）均有统计学显著降低。在基线时，组 1 的唾液 AA 水平显著高于组 2（P<0.01）。在 3 个月的随访中，组 1 和组 2 患者的全唾液 AA 水平没有显著差异。