Oral Health Prev Dent. 2021 Sep 30;19:481-488. doi: 10.3290/j.ohpd.b2082019.
The authors hypothesise that whole saliva soluble-urokinase-type plasminogen-activator receptor (suPAR) and tumor necrosis factor-alpha (TNF-α) levels are higher in patients with poorly-controlled than well-controlled type-2 diabetes mellitus (DM) and non-diabetic controls. The aim was to assess the periodontal clinicoradiographic status and whole-salivary suPAR and TNF-α levels in type-2 diabetic and non-diabetic individuals.
Patients with and without type-2 DM were included. In all patients, hemoglobin A1c (HbA1c) levels were measured. Participants were divided into 4 groups. Group 1: patients with poorly controlled type-2 DM; group 2: patients with well-controlled type-2 DM; group 3: non-diabetic patients with periodontitis; group 4: non-diabetic patients without periodontitis. Clinicoradiographic periodontal parameters (plaque index [PI], gingival index [GI], clinical attachment loss [AL], probing depth [PD] and mesial and distal marginal bone loss [MBL]) were measured. The whole saliva total protein concentration (TPC) and suPAR as well as TNF-α levels were measured. The level of statistical significance was set at p < 0.01.
One hundred patients (25 patients per group) were included. Scores of PI (p < 0.01), GI (p < 0.01), clinical AL (p < 0.01), PD (p < 0.01), number of missing teeth and mesial (p < 0.01) and distal (p < 0.01) MBL were statistically significantly higher in group 1 than in groups 2-4. Scores of PI, GI, clinical AL, PD, mesial and distal MBL, and numbers of missing teeth were higher in group 3 (p < 0.01) than in groups 2 and 4. The whole saliva TPC, suPAR and TNF-α levels were statistically significantly higher among patients in group 1 (p < 0.01) than in groups 2-4.
Patients with poorly-controlled type-2 DM presented with poorer clinicoradiographic periodontal status and increased whole saliva levels of suPAR, TNF-α and TPC compared with patients with well-controlled type-2 DM and non-diabetic individuals.
作者假设，与血糖控制良好的 2 型糖尿病（DM）患者和非糖尿病对照者相比，血糖控制不佳的 2 型 DM 患者的全唾液可溶性尿激酶型纤溶酶原激活物受体（suPAR）和肿瘤坏死因子-α（TNF-α）水平更高。本研究旨在评估 2 型糖尿病和非糖尿病个体的牙周临床放射学状况以及全唾液 suPAR 和 TNF-α水平。
纳入了有或无 2 型 DM 的患者。所有患者均测量了糖化血红蛋白（HbA1c）水平。参与者被分为 4 组。第 1 组：血糖控制不佳的 2 型 DM 患者；第 2 组：血糖控制良好的 2 型 DM 患者；第 3 组：患有牙周炎的非糖尿病患者；第 4 组：无牙周炎的非糖尿病患者。测量了牙周临床放射学参数（菌斑指数[PI]、牙龈指数[GI]、临床附着丧失[AL]、探诊深度[PD]和近远中边际骨丧失[MBL]）。测量了全唾液总蛋白浓度（TPC）和 suPAR 以及 TNF-α水平。统计显著性水平设定为 p < 0.01。
纳入了 100 名患者（每组 25 名患者）。第 1 组的 PI 评分（p < 0.01）、GI 评分（p < 0.01）、临床 AL 评分（p < 0.01）、PD 评分（p < 0.01）、缺牙数以及近中（p < 0.01）和远中（p < 0.01）MBL 评分均显著高于第 2-4 组。第 3 组的 PI 评分、GI 评分、临床 AL 评分、PD 评分、近中及远中 MBL 评分和缺牙数均高于第 2 组和第 4 组（p < 0.01）。第 1 组的全唾液 TPC、suPAR 和 TNF-α水平均显著高于第 2-4 组（p < 0.01）。
与血糖控制良好的 2 型 DM 患者和非糖尿病个体相比，血糖控制不佳的 2 型 DM 患者的牙周临床放射学状况较差，全唾液 suPAR、TNF-α 和 TPC 水平升高。
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