Medical School, Kunming University of Science and Technology, Chenggong District, No. 727, Southern Jingming Road, Kunming, Yunnan Province, 650500, People's Republic of China.
Curr Microbiol. 2022 Jul 14;79(9):247. doi: 10.1007/s00284-022-02928-z.
Noncoding RNAs (ncRNAs) represent the largest and main transcriptome products and play various roles in the biological activity of cells and pathological processes. Accumulating evidence shows that microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA) are important ncRNAs that play vital regulatory roles during viral infection. Hand-foot-mouth disease (HFMD) virus causes hand-foot-mouth disease, and is also associated with various serious complications and high mortality. However, there is currently no effective treatment. In this review, we focus on advances in the understanding of the modulatory role of ncRNAs during HFMD virus infection. Specifically, we discuss the generation, classification, and regulatory mechanisms of miRNA, lncRNA, and circRNA in the interaction between virus and host, with a particular focus on their influence with viral replication and infection. Analysis of these underlying mechanisms can help provide a foundation for the development of ncRNA-based antiviral therapies.
非编码 RNA（ncRNA）是最大和主要的转录组产物，在细胞的生物活性和病理过程中发挥各种作用。越来越多的证据表明，微小 RNA（miRNA）、长非编码 RNA（lncRNA）和环状 RNA（circRNA）是重要的 ncRNA，它们在病毒感染过程中发挥着重要的调节作用。手足口病（HFMD）病毒引起手足口病，还与各种严重并发症和高死亡率有关。然而，目前尚无有效的治疗方法。在这篇综述中，我们重点介绍了 ncRNA 在手足口病病毒感染过程中调节作用的研究进展。具体来说，我们讨论了 miRNA、lncRNA 和 circRNA 在病毒与宿主相互作用中的产生、分类和调控机制，特别关注它们对病毒复制和感染的影响。分析这些潜在的机制可以为基于 ncRNA 的抗病毒治疗方法的发展提供基础。
