Department of Orthopedics, 196534The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Institute of Orthopedics of Jiangxi Province, Nanchang, China.
J Biomater Appl. 2022 Nov;37(5):795-804. doi: 10.1177/08853282221114382. Epub 2022 Jul 14.
Surgical site infections (SSI) represent a considerable burden for healthcare systems. Studies show retrograde infection of the drainage tube is an important cause of surgical site infection. To this end, Surgeons work in various ways to reduce the incidence of retrograde infections. Fast progress in nanoscience and nanotechnology is revolutionizing the field of medicine to improve the quality of life due to the myriad of applications stemming from their unique properties, including the antibacterial activity against pathogens. Herein, we investigate the antibacterial properties of a novel nanomaterial composed of nano zinc oxide-decorated latex drainages. These materials were produced by the hydrothermal method and characterized through field-emission scanning electron microscopy (FE-SEM), X-ray diffraction (XRD), and DLS (Dynamic light scattering techniques). Then inductively coupled plasma mass spectrometry (ICP-MS) measurements showed that nano zinc oxide on the surface of the latex drainages showed a gradient release process. The antimicrobial activity of nano zinc oxide -decorated latex drainage was evaluated against and , the main bacteriological agent in the retrograde infection associated with drainage. The results showed that slices and rods nano zinc oxide (SAR-ZnO) drainage tubes had the best antibacterial properties both in vivo and in vitro. In addition, the cell viability assay demonstrated that nano zinc oxide-decorated latex drainages exerted good biocompatibility. Therefore, SAR-ZnO drainage tubes can be a perfect nanomaterial against the retrograde infection associated with drainage.
手术部位感染（SSI）给医疗系统带来了相当大的负担。研究表明，引流管逆行感染是手术部位感染的一个重要原因。为此，外科医生们采取了各种方法来降低逆行感染的发生率。纳米科学和纳米技术的快速发展正在彻底改变医学领域，由于其独特性质所带来的众多应用，包括对病原体的抗菌活性，从而提高了生活质量。在此，我们研究了一种由纳米氧化锌修饰的乳胶引流管组成的新型纳米材料的抗菌性能。这些材料是通过水热法制备的，并通过场发射扫描电子显微镜（FE-SEM）、X 射线衍射（XRD）和动态光散射技术（DLS）进行了表征。然后，电感耦合等离子体质谱（ICP-MS）测量表明，乳胶引流管表面的纳米氧化锌呈现出梯度释放过程。纳米氧化锌修饰的乳胶引流管的抗菌活性针对和 进行了评估，这是与引流相关的逆行感染的主要细菌学因子。结果表明，纳米氧化锌修饰的乳胶引流管在体内和体外都具有最好的抗菌性能。此外，细胞活力测定表明，纳米氧化锌修饰的乳胶引流管具有良好的生物相容性。因此，SAR-ZnO 引流管可以成为一种针对与引流相关的逆行感染的理想纳米材料。
