Sanz E, Boada J
Int J Clin Pharmacol Res. 1987;7(2):169-72.
In accordance with guidelines for a multicentre trial, the incidence and features of adverse drug reactions in a sample of 1327 children attending outpatient consultations have been determined. The incidence was of 0.75% (0.34% - 1.58% with p less than 0.05). The reactions were slight in character and predominantly affected very young female patients. Antibiotics were involved in almost a half of cases, and polypharmacy was used in all of them.
根据多中心试验指南，已确定了1327名门诊儿童样本中药物不良反应的发生率和特征。发生率为0.75%（0.34% - 1.58%，p < 0.05）。这些反应性质轻微，主要影响非常年幼的女性患者。几乎一半的病例涉及抗生素，且所有病例均使用了多种药物。
