Lu Yu, Deshmukh Subodh, Jones Ian, Chiu Yu-Lung
School of Metallurgy and Materials, University of Birmingham, Birmingham, UK.
Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK.
Biomater Transl. 2021 Sep 28;2(3):214-235. doi: 10.12336/biomatertransl.2021.03.005. eCollection 2021.
There is increasing interest in the development of bone repair materials for biomedical applications. Magnesium (Mg)-based alloys have a natural ability to biodegrade because they corrode in aqueous media; they are thus promising materials for orthopaedic device applications in that the need for a secondary surgical operation to remove the implant can be eliminated. Notably, Mg has superior biocompatibility because Mg is found in the human body in abundance. Moreover, Mg alloys have a low elastic modulus, close to that of natural bone, which limits stress shielding. However, there are still some challenges for Mg-based fracture fixation. The degradation of Mg alloys in biological fluids can be too rapid, resulting in a loss of mechanical integrity before complete healing of the bone fracture. In order to achieve an appropriate combination of bio-corrosion and mechanical performance, the microstructure needs to be tailored properly by appropriate alloy design, as well as the use of strengthening processes and manufacturing techniques. This review covers the evolution, current strategies and future perspectives of Mg-based orthopaedic implants.
用于生物医学应用的骨修复材料的开发正受到越来越多的关注。镁（Mg）基合金具有在水性介质中腐蚀从而自然降解的能力；因此，它们是骨科器械应用的有前途的材料，因为可以消除二次手术取出植入物的需求。值得注意的是，镁具有优异的生物相容性，因为人体中大量存在镁。此外，镁合金具有低弹性模量，接近天然骨的弹性模量，这限制了应力屏蔽。然而，镁基骨折固定仍存在一些挑战。镁合金在生物流体中的降解可能太快，导致在骨折完全愈合之前机械完整性丧失。为了实现生物腐蚀和机械性能的适当组合，需要通过适当的合金设计以及强化工艺和制造技术来适当地调整微观结构。本综述涵盖了镁基骨科植入物的发展历程、当前策略和未来展望。
