西咪替丁治疗6周前后，西咪替丁对五肽胃泌素刺激的胃酸和胃蛋白酶分泌的影响。

Effect of cimetidine on pentagastrin-stimulated gastric acid and pepsin secretion before and after 6 weeks of cimetidine treatment.

作者信息

Aadland E, Berstad A

出版信息

Scand J Gastroenterol. 1978;13(2):193-7. doi: 10.3109/00365527809181747.

Abstract

To see whether the effect of cimetidine changes during a treatment period, the effect of intravenous cimetidine on pentagastrin-stimulated gastric acid and pepsin secretion was studied before and after a 6-week course of oral cimetidine treatment, 1 g/day, in 10 duodenal ulcer patients. Pentagastrin, 1.5 microgram . kg-1 . h-1, was infused for 165 min, and cimetidine, 1.2 mg . kg-1 . h-1, was added by concomitant infusion during the last 90 min. The second secretion test was carried out 60 hours after the last dose of cimetidine. Acid and pepsin secretion, in response to pentagastrin stimulation, was not significantly changed after 6 weeks of daily cimetidine treatment. The response to pentagastrin plus cimetidine was, however, significantly higher at the end than at the start of the treatment period. The results suggested a slightly reduced effect of cimetidine after prolonged use.

摘要

为了观察西咪替丁在治疗期间的效果是否发生变化，对10例十二指肠溃疡患者进行了研究，在口服西咪替丁（1g/天）6周疗程前后，静脉注射西咪替丁对五肽胃泌素刺激的胃酸和胃蛋白酶分泌的影响。以1.5μg·kg⁻¹·h⁻¹的速度输注五肽胃泌素165分钟，在最后90分钟通过同步输注加入1.2mg·kg⁻¹·h⁻¹的西咪替丁。在最后一剂西咪替丁给药60小时后进行第二次分泌试验。每日服用西咪替丁6周后，五肽胃泌素刺激引起的胃酸和胃蛋白酶分泌没有明显变化。然而，五肽胃泌素加西咪替丁的反应在治疗期结束时明显高于开始时。结果表明长期使用后西咪替丁的效果略有降低。