西咪替丁长期治疗对人体胃酸分泌的影响。
Effect of prolonged cimetidine therapy on gastric acid secretion in man.
作者信息
Barbezat G O, Bank S
出版信息
Gut. 1978 Feb;19(2):151-4. doi: 10.1136/gut.19.2.151.
Abstract
In a double blind trial, 23 patients with endoscopically confirmed duodenal ulceration received cimetidine (300 mg four times daily in six patients, or 400 mg four times daily in 10 patients) or placebo (seven patients) for six weeks. Before entry into the trial, pentagastrin (6 microgram.kg-1.h-1)--stimulated gastric acid secretion after a single oral dose of 300 or 400 mg cimetidine was lowered by 82.1% and 81.0%, respectively, while no significant inhibition was recorded in the patients receiving placebo (8.8%). The same test repeated after six weeks of continuous treatment showed that the effect of the drug was maintained, the percentage inhibition of acid secretion being of the same order as in the first test.
摘要
在一项双盲试验中，23例经内镜确诊为十二指肠溃疡的患者接受了西咪替丁治疗（6例患者每日4次，每次300毫克；10例患者每日4次，每次400毫克）或安慰剂治疗（7例患者），为期6周。在进入试验前，五肽胃泌素（6微克·千克⁻¹·小时⁻¹）刺激的胃酸分泌在单次口服300毫克或400毫克西咪替丁后分别降低了82.1%和81.0%，而接受安慰剂的患者未观察到显著抑制作用（8.8%）。连续治疗6周后重复相同测试表明，药物效果得以维持，胃酸分泌抑制百分比与首次测试处于同一水平。
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