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医疗和外科患者延长静脉血栓栓塞预防的挑战。

Challenges of extended venous thromboembolism prophylaxis in medical and surgical patients.

作者信息

Chindamo Maria Chiara, Paiva Edison Ferreira, do Carmo Plinio Resende, Rocha Ana Thereza Cavalcanti, Marques Marcos Arêas

机构信息

Universidade Federal do Rio de Janeiro - UFRJ, Rio de Janeiro, RJ, Brasil.

Hospital Barra D'Or, Rede D'Or São Luiz, Rio de Janeiro, RJ, Brasil.

出版信息

J Vasc Bras. 2022 Jun 27;21:e20210195. doi: 10.1590/1677-5449.202101951. eCollection 2022.

DOI:10.1590/1677-5449.202101951
PMID:35836745
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9250351/
Abstract

Patients hospitalized for acute medical and surgical illnesses are at risk of developing venous thromboembolism (VTE) during hospitalization and after discharge. Extended pharmacological prophylaxis beyond the hospital stay is recommended for patients undergoing surgeries at high risk for VTE and for selected groups of hospitalized medical patients. This practice involves several challenges, from identification of at-risk populations eligible for extended prophylaxis to choice of the most appropriate anticoagulant and definition of the ideal duration of use. This review will present the main VTE risk assessment models for hospitalized medical and surgical patients, the current recommendations for use of extended prophylaxis, and its limitations and benefits.

摘要

因急性内科和外科疾病住院的患者在住院期间及出院后有发生静脉血栓栓塞(VTE)的风险。对于VTE高危手术患者及部分住院内科患者,建议在出院后延长药物预防时间。这种做法面临诸多挑战,从确定适合延长预防的高危人群,到选择最合适的抗凝剂以及确定理想的使用时长。本综述将介绍针对住院内科和外科患者的主要VTE风险评估模型、目前关于延长预防的使用建议及其局限性和益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3b/9250351/a1018ad719be/jvb-21-e20210195-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3b/9250351/fef7823eb5bd/jvb-21-e20210195-g01-en.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3b/9250351/a1018ad719be/jvb-21-e20210195-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3b/9250351/fef7823eb5bd/jvb-21-e20210195-g01-en.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d3b/9250351/a1018ad719be/jvb-21-e20210195-g01.jpg

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本文引用的文献

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Prevention of Venous Thromboembolism in Acutely Ill Medical Patients: A New Era.急性病医学患者静脉血栓栓塞症的预防:新时代。
Semin Respir Crit Care Med. 2021 Apr;42(2):308-315. doi: 10.1055/s-0041-1723018. Epub 2021 Feb 6.
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Thromboembolism Prophylaxis for Patients Discharged From the Hospital: Easier Said Than Done.出院患者的血栓栓塞预防:说起来容易做起来难。
J Am Coll Cardiol. 2020 Jun 30;75(25):3148-3150. doi: 10.1016/j.jacc.2020.05.023.
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Extended Venous Thromboembolism Prophylaxis in Medically Ill Patients: An NATF Anticoagulation Action Initiative.
内科疾病患者的静脉血栓栓塞症延伸预防:NATF 抗凝行动倡议。
Am J Med. 2020 May;133 Suppl 1:1-27. doi: 10.1016/j.amjmed.2019.12.001.
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Improved Benefit Risk Profile of Rivaroxaban in a Subpopulation of the MAGELLAN Study.在 MAGELLAN 研究的一个亚组中,利伐沙班的获益风险状况得到改善。
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Syst Rev. 2019 Oct 30;8(1):249. doi: 10.1186/s13643-019-1179-1.
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Venous Thromboembolism Prophylaxis and Treatment in Patients With Cancer: ASCO Clinical Practice Guideline Update.静脉血栓栓塞症预防和治疗癌症患者:ASCO 临床实践指南更新。
J Clin Oncol. 2020 Feb 10;38(5):496-520. doi: 10.1200/JCO.19.01461. Epub 2019 Aug 5.
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Determination of Risk Factors for Venous Thromboembolism by an Adapted Caprini Scoring System in Surgical Patients.采用改良Caprini评分系统确定外科手术患者静脉血栓栓塞的危险因素
J Pers Med. 2019 Jul 17;9(3):36. doi: 10.3390/jpm9030036.
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The IMPROVEDD VTE Risk Score: Incorporation of D-Dimer into the IMPROVE Score to Improve Venous Thromboembolism Risk Stratification.改良的VTE风险评分:将D-二聚体纳入改良评分以改善静脉血栓栓塞风险分层。
TH Open. 2017 Jun 28;1(1):e56-e65. doi: 10.1055/s-0037-1603929. eCollection 2017 Jun.
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Extended prophylaxis for venous thromboembolism after hospitalization for medical illness: A trial sequential and cumulative meta-analysis.因病住院后静脉血栓栓塞症的延长预防:一项试验序贯和累积荟萃分析。
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Extended venous thromboembolism prophylaxis after abdominopelvic cancer surgery: a retrospective review.腹盆部癌症手术后的延伸静脉血栓栓塞预防:一项回顾性研究。
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