• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

新型功能性 eQTL-SNPs 与儿童肺炎易感性相关。

Novel Functional eQTL-SNPs Associated With Susceptibility to Pneumonia in Children.

机构信息

Department of Epidemiology, School of Public Health, Nantong University, Nantong, China.

Department of Pediatrics, No. 8 People's Hospital of Wuxi, Wuxi, China.

出版信息

Front Public Health. 2022 Jun 28;10:899045. doi: 10.3389/fpubh.2022.899045. eCollection 2022.

DOI:10.3389/fpubh.2022.899045
PMID:35836993
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9273990/
Abstract

BACKGROUND

The functional causal single-nucleotide polymorphisms (SNPs) associated with susceptibility to Pneumonia (MPP) have scarcely been identified. In this study, we aimed to analyze the association between the functional expression quantitative trait locus (eQTL)-SNPs and the risk of MPP.

METHODS

First, we identified reported genes associated with MPP from the human disease database, MalaCards. After investigating multiple databases, we systematically selected seven functional eQTL-SNPs (rs2070874, rs360720, rs8032531, rs4316, rs4353, rs7258241, and rs2250656). Finally, the selected eQTL-SNPs were genotyped using the TaqMan genotyping technology, and compared between 100 children with MPP and 178 healthy controls.

RESULTS

We found that three eQTL-SNPs (rs8032531 in and rs4316 and rs4353 in ) were significantly associated with susceptibility to MPP. Joint analysis of the three eQTL-SNPs revealed that the risk of MPP increased with an increase in the number of risk alleles present. Plasma protein expression levels of CD276 and ACE were distinctively higher in children with MPP than in healthy children (CD276: < 0.001; ACE: = 0.001).

CONCLUSION

Functional eQTL-SNPs in and may affect the susceptibility to MPP. The risk of developing MPP is higher in patients harboring a greater number of unfavorable alleles of the aforementioned SNPs.

摘要

背景

与肺炎易感性相关的功能性因果单核苷酸多态性（SNP）尚未被确定。本研究旨在分析功能表达数量性状基因座（eQTL）-SNP 与肺炎易感性之间的关联。

方法

首先，我们从人类疾病数据库 MalaCards 中鉴定出与肺炎相关的报告基因。在调查了多个数据库后，我们系统地选择了七个功能 eQTL-SNP（rs2070874、rs360720、rs8032531、rs4316、rs4353、rs7258241 和 rs2250656）。最后，使用 TaqMan 基因分型技术对选定的 eQTL-SNP 进行基因分型，并在 100 名肺炎患儿和 178 名健康对照者之间进行比较。

结果

我们发现三个 eQTL-SNP（位于 的 rs8032531、位于 和 的 rs4316 和 rs4353）与肺炎易感性显著相关。三个 eQTL-SNP 的联合分析表明，随着风险等位基因数的增加，肺炎的发病风险增加。与健康儿童相比，肺炎患儿的 CD276 和 ACE 血浆蛋白表达水平明显升高（CD276：<0.001；ACE：=0.001）。

结论

位于 和 中的功能性 eQTL-SNP 可能影响肺炎的易感性。携带上述 SNP 不利等位基因数量较多的患者发生肺炎的风险更高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/bf3102fbbc78/fpubh-10-899045-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/6f9f4f713485/fpubh-10-899045-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/64e95725d99c/fpubh-10-899045-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/32ac412f8662/fpubh-10-899045-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/2a8a220154b0/fpubh-10-899045-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/bf3102fbbc78/fpubh-10-899045-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/6f9f4f713485/fpubh-10-899045-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/64e95725d99c/fpubh-10-899045-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/32ac412f8662/fpubh-10-899045-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/2a8a220154b0/fpubh-10-899045-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f52/9273990/bf3102fbbc78/fpubh-10-899045-g0005.jpg

相似文献

1
Novel Functional eQTL-SNPs Associated With Susceptibility to Pneumonia in Children.新型功能性 eQTL-SNPs 与儿童肺炎易感性相关。
Front Public Health. 2022 Jun 28;10:899045. doi: 10.3389/fpubh.2022.899045. eCollection 2022.
2
Association of the ACE, GSTM1, IL-6, NOS3, and CYP1A1 polymorphisms with susceptibility of mycoplasma pneumoniae pneumonia in Chinese children.ACE、GSTM1、IL-6、NOS3和CYP1A1基因多态性与中国儿童肺炎支原体肺炎易感性的关联
Medicine (Baltimore). 2017 Apr;96(15):e6642. doi: 10.1097/MD.0000000000006642.
3
The role of miR-29c/B7-H3/Th17 axis in children with Mycoplasma pneumoniae pneumonia.miR-29c/B7-H3/Th17 轴在儿童肺炎支原体肺炎中的作用。
Ital J Pediatr. 2019 May 14;45(1):61. doi: 10.1186/s13052-019-0655-5.
4
Identify clinical factors related to Mycoplasma pneumoniae pneumonia with hypoxia in children.确定与儿童支原体肺炎伴低氧血症相关的临床因素。
BMC Infect Dis. 2020 Jul 22;20(1):534. doi: 10.1186/s12879-020-05270-6.
5
Respiratory microbiota imbalance in children with Mycoplasma pneumoniae pneumonia.儿童肺炎支原体肺炎的呼吸微生物群失衡。
Emerg Microbes Infect. 2023 Dec;12(1):2202272. doi: 10.1080/22221751.2023.2202272.
6
Prediction of risk factors of bronchial mucus plugs in children with Mycoplasma pneumoniae pneumonia.预测肺炎支原体肺炎患儿支气管黏液栓形成的危险因素。
BMC Infect Dis. 2021 Jan 13;21(1):67. doi: 10.1186/s12879-021-05765-w.
7
Transcriptome analysis of bronchoalveolar lavage fluid from children with severe Mycoplasma pneumoniae pneumonia reveals novel gene expression and immunodeficiency.重症肺炎支原体肺炎患儿支气管肺泡灌洗液的转录组分析揭示了新的基因表达和免疫缺陷。
Hum Genomics. 2017 Mar 16;11(1):4. doi: 10.1186/s40246-017-0101-y.
8
Increased Serum Interleukin-10 but not Interleukin-4 Level in Children with Mycoplasma pneumoniae Pneumonia.肺炎支原体肺炎患儿血清白细胞介素-10水平升高而白细胞介素-4水平未升高。
J Trop Pediatr. 2017 Aug 1;63(4):294-300. doi: 10.1093/tropej/fmw091.
9
Plasma soluble B7-H3 levels for severity evaluation in pediatric patients with Mycoplasma pneumoniae pneumonia.用于评估儿童肺炎支原体肺炎严重程度的血浆可溶性 B7-H3 水平。
Int Immunopharmacol. 2019 Aug;73:163-171. doi: 10.1016/j.intimp.2019.05.014. Epub 2019 May 14.
10
Airway microbiota in children with bronchial mucus plugs caused by Mycoplasma pneumoniae pneumonia.肺炎支原体肺炎致支气管黏液栓患儿的气道微生物群。
Respir Med. 2020 Aug-Sep;170:105902. doi: 10.1016/j.rmed.2020.105902. Epub 2020 Feb 15.

本文引用的文献

1
The risk to child nutrition during and after COVID-19 pandemic: what to expect and how to respond.新冠疫情期间和之后对儿童营养的风险：需要注意什么和如何应对。
Public Health Nutr. 2021 Aug;24(11):3530-3536. doi: 10.1017/S1368980021001610. Epub 2021 Apr 13.
2
Dynamic change of pneumonia in hospitalized children in a general hospital: a 3-year retrospective analysis.一家综合医院住院儿童肺炎的动态变化：一项为期3年的回顾性分析。
Transl Pediatr. 2020 Aug;9(4):522-531. doi: 10.21037/tp-20-149.
3
Severe Mycoplasma pneumoniae pneumonia requiring intensive care in children, 2010-2019.
2010-2019 年儿童重症肺炎支原体肺炎需重症监护治疗。
J Formos Med Assoc. 2021 Jan;120(1 Pt 1):281-291. doi: 10.1016/j.jfma.2020.08.018. Epub 2020 Sep 15.
4
Angiotensin-Converting Enzyme Gene Polymorphism and Severe Lung Injury in Patients with Coronavirus Disease 2019.血管紧张素转化酶基因多态性与 2019 年冠状病毒病患者的严重肺损伤。
Am J Pathol. 2020 Oct;190(10):2013-2017. doi: 10.1016/j.ajpath.2020.07.009. Epub 2020 Jul 29.
5
Role of angiotensin-converting enzyme in myeloid cell immune responses.血管紧张素转换酶在髓样细胞免疫应答中的作用。
Cell Mol Biol Lett. 2020 May 25;25:31. doi: 10.1186/s11658-020-00225-w. eCollection 2020.
6
The Coronavirus Disease 2019 (COVID-19) Pandemic.新型冠状病毒肺炎（COVID-19）疫情。
Tohoku J Exp Med. 2020 Apr;250(4):271-278. doi: 10.1620/tjem.250.271.
7
Changes and Significance of Serum sB7-H3 and Cytokines in Children with Mycoplasma pneumonae Pneumonia.血清 sB7-H3 及细胞因子在小儿肺炎支原体肺炎中的变化及意义。
J Coll Physicians Surg Pak. 2020 Mar;30(3):268-271. doi: 10.29271/jcpsp.2020.03.268.
8
B7-H3: A promising therapeutic target for autoimmune diseases.B7-H3：自身免疫性疾病有前景的治疗靶点。
Cell Immunol. 2020 Jun;352:104077. doi: 10.1016/j.cellimm.2020.104077. Epub 2020 Feb 21.
9
Overexpression of ACE in Myeloid Cells Increases Immune Effectiveness and Leads to a New Way of Considering Inflammation in Acute and Chronic Diseases.髓系细胞中ACE的过表达可提高免疫效能，并为急性和慢性疾病中炎症的考量提供新途径。
Curr Hypertens Rep. 2020 Jan 8;22(1):4. doi: 10.1007/s11906-019-1008-x.
10
The epidemiology of paediatric Mycoplasma pneumoniae pneumonia in North China: 2006 to 2016.华北地区儿童肺炎支原体肺炎的流行病学：2006 年至 2016 年。
Epidemiol Infect. 2019 Jan;147:e192. doi: 10.1017/S0950268819000839.