与抗生素庆大霉素和环丙沙星联用的叶部分最高剂量组合活性筛选
The Highest Dosage Combination Activity Screening from the Leaf Fraction of with Antibiotic Gentamicin and Ciprofloxacin.
作者信息
Sari Rafika, Pratiwi Liza, Apridamayanti Pratiwi
机构信息
Faculty of Medical Science, Tanjungpura University, Pontianak, Indonesia.
出版信息
J Pharmacopuncture. 2022 Jun 30;25(2):101-105. doi: 10.3831/KPI.2022.25.2.101.
OBJECTIVES
This study aims to determine the Fractional Inhibitory Concentration Index (FICI) of combinations of leaf fraction with ciprofloxacin or gentamicin against pathogenic bacteria, , , and , isolated from Diabetic Foot Ulcer (DFU) patients.
METHODS
We tested concentrations of 45%, 55%, 65%, and 75% of gentamicin and ciprofloxacin using dilution and agar diffusion methods. The combination of leaf extract with these antibiotics was tested against all three bacteria.
RESULTS
The combination of leaf extract and ciprofloxacin gave a FICI value of 0.5, indicating synergistic antibacterial activity against the test bacteria.
CONCLUSION
The results show that the antibacterial effect of a combination of high doses of the leaf extract with either antibiotic is greater than that of the leaf extract and the antibiotics in single use.
目的
本研究旨在确定从糖尿病足溃疡（DFU）患者中分离出的 、 、 和 等病原菌，其叶提取物与环丙沙星或庆大霉素联合使用时的联合抑菌浓度指数（FICI）。
方法
我们采用稀释法和琼脂扩散法测试了庆大霉素和环丙沙星浓度分别为45%、55%、65%和75%时的情况。将叶提取物与这些抗生素的组合针对所有三种细菌进行了测试。
结果
叶提取物与环丙沙星的组合产生的FICI值为0.5，表明对测试细菌具有协同抗菌活性。
结论
结果表明，高剂量叶提取物与任一抗生素联合使用的抗菌效果大于叶提取物和抗生素单独使用时的抗菌效果。
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