Zhang Yuyu, Chen Zhejie, Chen Liping, Dong Qin, Yang Dong-Hua, Zhang Qi, Zeng Jing, Wang Yang, Liu Xiao, Cui Yuan, Li Minglong, Luo Xiao, Zhou Chongjian, Ye Mingzhu, Li Ling, He Yuxin
School of Food and Bioengineering, Xihua University, Chengdu, 610039, China.
Institute of Molecular Medicine (IMM), Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, China.
Chin Med. 2024 Aug 30;19(1):119. doi: 10.1186/s13020-024-00977-z.
Astragali radix (AR, namded Huangqi in Chinese) is the dried root of Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus (Fisch.) Bge. As a widely used ethnomedicine, the biological activities of AR include immunomodulatory, anti-hyperglycemic, anti-oxidant, anti-aging, anti-inflammatory, anti-viral, anti-tumor, cardioprotective, and anti-diabetic effects, with minimum side effects. Currently, it is known that polysaccharides, saponins, and flavonoids are the indispensable components of AR. In this review, we will elaborate the research advancements of AR on ethnobotany, ethnopharmacological practices, phytochemicals, pharmacological activities, clinical uses, quality control, production developments, and toxicology. The information is expected to assist clinicians and scientists in developing useful therapeutic medicines with minimal systemic side effects.
黄芪是蒙古黄芪或膜荚黄芪的干燥根。作为一种广泛使用的民族药物，黄芪的生物活性包括免疫调节、抗高血糖、抗氧化、抗衰老、抗炎、抗病毒、抗肿瘤、心脏保护和抗糖尿病作用，且副作用最小。目前已知多糖、皂苷和黄酮类化合物是黄芪不可或缺的成分。在这篇综述中，我们将阐述黄芪在民族植物学、民族药理学实践、植物化学、药理活性、临床应用、质量控制、生产发展和毒理学方面的研究进展。这些信息有望帮助临床医生和科学家开发出具有最小全身副作用的有用治疗药物。
