Katz Austen D, Song Junho, Virk Sohrab, Silber Jeff Scott, Essig David
Department of Orthopedic Surgery, North Shore University Hospital-Long Island Jewish Medical Center, Zucker School of Medicine at Hofstra/Northwell, NY, USA.
J Craniovertebr Junction Spine. 2022 Apr-Jun;13(2):182-191. doi: 10.4103/jcvjs.jcvjs_60_22. Epub 2022 Jun 13.
Despite increasing utilization of fusion to treat degenerative pathology, few studies have evaluated outcomes with pelvic fixation (PF). This is the first large-scale database study to compare multilevel fusion with and without PF for degenerative lumbar disease.
The aim of this study was to compare the 30-day outcomes of multilevel lumbar fusion with and without PF.
This was a retrospective cohort study.
Lumbar fusion patients were identified using the National Surgical Quality Improvement Program database. Regression was utilized to analyze readmission, reoperation, morbidity, and specific complications and to evaluate for predictors thereof.
Student's -test was used for continuous variables and Chi-squared or Fisher's exact test was used for categorical variables. Variables significant in the univariate analyses ( < 0.05) and PF were then evaluated for significance as independent predictors and control variables in a series of multivariate logistic regression analyses of primary outcomes.
We identified 38,413 patients. PF predicted 30-day readmission and morbidity. PF was associated with greater reoperation in univariate analysis, but not in multivariate analyses. PF predicted deep wound infections, organ-space infections, pulmonary complications, urinary tract infection, transfusion, deep venous thrombosis, and sepsis. PF was also associated with a longer hospital stay. Age, obesity, steroids, and American Society of Anesthesiologists (ASA) class ≥ 3 predicted readmission. Obesity, steroids, bleeding disorder, preoperative transfusion, ASA class ≥3, and levels fused predicted reoperation. Age, African American race, decreased hematocrit, obesity, hypertension, dyspnea, steroids, bleeding disorder, ASA class ≥3, levels fused, and interbody levels fused predicted morbidity. Male gender and inclusion of anterior lumbar interbody fusion (ALIF) were protective of reoperation. Hispanic ethnicity, ALIF, and computer-assisted surgery (CAS) were protective of morbidity.
Adjunctive PF was associated with a 1.5-times and 2.7-times increased odds of readmission and morbidity, respectively. ASA class and specific comorbidities predicted poorer outcomes, while ALIF and CAS were protective. These findings can guide surgical solutions given specific patient factors.
尽管融合术在治疗退行性病变中的应用日益增加,但很少有研究评估骨盆固定(PF)的疗效。这是第一项比较有和没有PF的多节段融合术治疗退行性腰椎疾病的大规模数据库研究。
本研究的目的是比较有和没有PF的多节段腰椎融合术的30天疗效。
这是一项回顾性队列研究。
使用国家外科质量改进计划数据库识别腰椎融合术患者。采用回归分析来分析再入院、再次手术、发病率和特定并发症,并评估其预测因素。
连续变量采用学生t检验,分类变量采用卡方检验或Fisher精确检验。在单因素分析中具有显著性的变量(P<0.05)和PF随后在一系列主要结局的多因素逻辑回归分析中作为独立预测因素和对照变量评估其显著性。
我们识别出38413例患者。PF可预测30天再入院和发病率。在单因素分析中,PF与更高的再次手术率相关,但在多因素分析中并非如此。PF可预测深部伤口感染、器官间隙感染、肺部并发症、尿路感染、输血、深静脉血栓形成和脓毒症。PF还与更长的住院时间相关。年龄、肥胖、使用类固醇以及美国麻醉医师协会(ASA)分级≥3可预测再入院。肥胖、使用类固醇、出血性疾病、术前输血、ASA分级≥3以及融合节段可预测再次手术。年龄、非裔美国人种族、血细胞比容降低、肥胖、高血压、呼吸困难、使用类固醇、出血性疾病、ASA分级≥3、融合节段以及椎间融合节段可预测发病率。男性性别和纳入腰椎前路椎间融合术(ALIF)可降低再次手术风险。西班牙裔种族、ALIF和计算机辅助手术(CAS)可降低发病风险。
辅助性PF分别使再入院几率和发病率增加1.5倍和2.7倍。ASA分级和特定合并症预示预后较差,而ALIF和CAS具有保护作用。这些发现可为考虑特定患者因素的手术方案提供指导。