Du Yukun, Li Jianyi, Tang Xiaojie, Liu Yingying, Bian Guoshuai, Shi Jianzhuang, Zhang Yixin, Zhao Baomeng, Zhao Hongri, Sui Kunyan, Xi Yongming
Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
Department of Spinal Surgery, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Front Bioeng Biotechnol. 2022 Jun 28;10:876157. doi: 10.3389/fbioe.2022.876157. eCollection 2022.
Percutaneous endoscopic lumbar discectomy has been widely used in clinical practice for lumbar spine diseases. But the postoperative disc re-herniation and inflammation are the main reason for pain recurrence after surgery. The postoperative local defect of the intervertebral disc will lead to the instability of the spine, further aggravating the process of intervertebral disc degeneration. In this work, we successfully synthesized the thermosensitive injectable celecoxib-loaded chitosan hydrogel and investigated its material properties, repair effect, biocompatibility, and histocompatibility in and in vivo study. and in vivo, the hydrogel has low toxicity, biodegradability, and good biocompatibility. In an animal experiment, this composite hydrogel can effectively fill local tissue defects to maintain the stability of the spine and delay the process of intervertebral disc degeneration after surgery. These results indicated that this composite hydrogel will be a promising way to treat postoperative intervertebral disc disease in future clinical applications.
经皮内镜下腰椎间盘切除术已在临床实践中广泛用于治疗腰椎疾病。但术后椎间盘再突出和炎症是手术后疼痛复发的主要原因。术后椎间盘局部缺损会导致脊柱不稳定，进一步加速椎间盘退变进程。在本研究中，我们成功合成了载有塞来昔布的热敏性可注射壳聚糖水凝胶，并在体外和体内研究中考察了其材料性能、修复效果、生物相容性和组织相容性。在体外和体内，该水凝胶均具有低毒性、可生物降解性和良好的生物相容性。在动物实验中，这种复合水凝胶可有效填充局部组织缺损，维持脊柱稳定性，并延缓术后椎间盘退变进程。这些结果表明，这种复合水凝胶在未来临床应用中有望成为治疗术后椎间盘疾病的一种方法。
