HonorHealth Research and Innovation Institute, Scottsdale, Arizona.
Department of Medicine, University of Arizona College of Medicine- Phoenix, Phoenix, Arizona.
Cancer Res. 2022 Oct 17;82(20):3650-3658. doi: 10.1158/0008-5472.CAN-22-0887.
Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.
肿瘤治疗电场（TTFields）是一种新型的癌症治疗方式，通过经皮传递到肿瘤。FDA 已批准 TTFields 用于治疗多形性胶质母细胞瘤和间皮瘤，目前正在许多其他癌症类型中进行研究。虽然抗有丝分裂作用是 TTFields 最初被识别的抗肿瘤活性，但数据表明，肿瘤治疗电场通过多种作用机制发挥抗肿瘤作用。因此，肿瘤治疗电场具有与许多不同治疗方式联合用于多种癌症类型的潜力。在此，我们综述了 TTFields 的现有认识及其作用机制。
