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有机染料的催化降解表明磁电纳米颗粒具有抗增殖作用。

Catalytic Degradation of Organic Dyes Indicates Anti-Proliferative Effects of Magnetoelectric Nanoparticles.

作者信息

Shotbolt Max, Zhu Emily, Andre Victoria, Zhang Elric, Duran Isabelle, Bryant John, El-Rifai Wael, Liang Ping, Khizroev Sakhrat

机构信息

University of Miami, McArthur Engineering Building, Memorial Dr, Coral Gables, FL 33146 USA.

Miami Palmetto Highschool, 7431 SW 120th St, Pinecrest, FL 33156 USA.

出版信息

J Electron Mater. 2025;54(7):5529-5538. doi: 10.1007/s11664-025-11843-5. Epub 2025 Mar 11.


DOI:10.1007/s11664-025-11843-5
PMID:40491600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12145325/
Abstract

Over the past decade, magnetoelectric nanoparticles (MENPs) have proven effective in generating local electric fields in response to stimulation with a magnetic field. The applications of such nanoparticles are many and varied, with examples of prior research including use for on-demand drug release, wireless modulation and recording of neural activity, and organic dye degradation. This study investigates the potential for organic dye degradation to be used as a rapid and efficient screening tool to detect the magnetoelectric effect of MENPs, and how the results of such a test mirror the antiproliferative effect of said nanoparticles. Trypan blue was selected as an azo dye to test for dye degradation. Vials of the dye were treated with CoFe2O4@BaTiO3 core-shell MENPs of varying characteristics, both with and without concurrent 1-kHz 250-Oe magnetic stimulation. Dye degradation was measured using ultraviolet (UV)-vis spectroscopy. Dye degradation efficacy varied with varying nanoparticle synthesis parameters. As controls, nanoparticles of the same composition, but with an insignificant magnetoelectric effect, were used. SKOV-3 ovarian cancer cells were then treated with the same nanoparticles, and viability was measured with an adenosine triphosphate (ATP) assay. These measurements show a decrease in cell viability up to 60.3% of control ( = 0.0052), which mirrored the efficacy of dye degradation of up to 69.8% ( = 0.0037) in each of the particle variants, demonstrating the value of azo dye degradation as a simple screening test for MENPs, and showing the potential of MENPs used as wirelessly controlled nanodevices to allow targeted electric field-based treatments.

摘要

在过去十年中,磁电纳米颗粒(MENPs)已被证明在响应磁场刺激时能够有效地产生局部电场。这类纳米颗粒的应用广泛多样,先前的研究实例包括用于按需药物释放、神经活动的无线调制和记录以及有机染料降解。本研究调查了将有机染料降解用作快速高效的筛选工具以检测MENPs磁电效应的潜力,以及这种测试结果如何反映所述纳米颗粒的抗增殖效应。选择台盼蓝作为一种偶氮染料来测试染料降解情况。将装有该染料的小瓶用具有不同特性的CoFe2O4@BaTiO3核壳型MENPs进行处理,同时有或没有1kHz 250Oe的磁刺激。使用紫外可见光谱法测量染料降解情况。染料降解效率随纳米颗粒合成参数的变化而变化。作为对照,使用了相同组成但磁电效应不显著的纳米颗粒。然后用相同的纳米颗粒处理SKOV - 3卵巢癌细胞,并通过三磷酸腺苷(ATP)测定法测量细胞活力。这些测量结果显示细胞活力下降至对照的60.3%(P = 0.0052),这反映了每个颗粒变体中高达69.8%(P = 0.0037)的染料降解效率,证明了偶氮染料降解作为MENPs简单筛选测试的价值,并显示了MENPs用作无线控制纳米器件以实现基于电场的靶向治疗的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/39959c0a0683/11664_2025_11843_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/09397e2a5823/11664_2025_11843_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/555d8f1cbd14/11664_2025_11843_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/4f49666afa41/11664_2025_11843_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/7495ee216458/11664_2025_11843_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/39959c0a0683/11664_2025_11843_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/09397e2a5823/11664_2025_11843_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/555d8f1cbd14/11664_2025_11843_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/4f49666afa41/11664_2025_11843_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/7495ee216458/11664_2025_11843_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ddd3/12145325/39959c0a0683/11664_2025_11843_Fig7_HTML.jpg

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Catalytic Degradation of Organic Dyes Indicates Anti-Proliferative Effects of Magnetoelectric Nanoparticles.

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本文引用的文献

[1]
Well-balanced performance achieved in PZT piezoceramics a multiscale regulation strategy.

Mater Horiz. 2024-10-28

[2]
Multiscale Modeling of Magnetoelectric Nanoparticles for the Analysis of Spatially Selective Neural Stimulation.

Adv Healthc Mater. 2024-9

[3]
Magnetic-Field-Assisted Electric-Field-Induced Domain Switching of a Magnetic Single Domain in a Multiferroic/Magnetoelectric Ni Nanochevron/[Pb(MgNb)O]-[PbTiO] (PMN-PT) Layered Structure.

Micromachines (Basel). 2023-12-23

[4]
An overview of the irreversible electroporation for the treatment of liver metastases: When to use it.

Front Oncol. 2022-9-1

[5]
The Mechanisms of Action of Tumor Treating Fields.

Cancer Res. 2022-10-17

[6]
Electroporation and Immunotherapy-Unleashing the Abscopal Effect.

Cancers (Basel). 2022-6-10

[7]
In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles.

Sci Rep. 2022-5-19

[8]
MRI-Guided, Noninvasive Delivery of Magneto-Electric Drug Nanocarriers to the Brain in a Nonhuman Primate.

ACS Appl Bio Mater. 2019-11-18

[9]
Tumor Treating Fields for Ovarian Carcinoma: A Modeling Study.

Adv Radiat Oncol. 2021-5-17

[10]
In Vivo Wireless Brain Stimulation via Non-invasive and Targeted Delivery of Magnetoelectric Nanoparticles.

Neurotherapeutics. 2021-7

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