Shotbolt Max, Zhu Emily, Andre Victoria, Zhang Elric, Duran Isabelle, Bryant John, El-Rifai Wael, Liang Ping, Khizroev Sakhrat
University of Miami, McArthur Engineering Building, Memorial Dr, Coral Gables, FL 33146 USA.
Miami Palmetto Highschool, 7431 SW 120th St, Pinecrest, FL 33156 USA.
J Electron Mater. 2025;54(7):5529-5538. doi: 10.1007/s11664-025-11843-5. Epub 2025 Mar 11.
Over the past decade, magnetoelectric nanoparticles (MENPs) have proven effective in generating local electric fields in response to stimulation with a magnetic field. The applications of such nanoparticles are many and varied, with examples of prior research including use for on-demand drug release, wireless modulation and recording of neural activity, and organic dye degradation. This study investigates the potential for organic dye degradation to be used as a rapid and efficient screening tool to detect the magnetoelectric effect of MENPs, and how the results of such a test mirror the antiproliferative effect of said nanoparticles. Trypan blue was selected as an azo dye to test for dye degradation. Vials of the dye were treated with CoFe2O4@BaTiO3 core-shell MENPs of varying characteristics, both with and without concurrent 1-kHz 250-Oe magnetic stimulation. Dye degradation was measured using ultraviolet (UV)-vis spectroscopy. Dye degradation efficacy varied with varying nanoparticle synthesis parameters. As controls, nanoparticles of the same composition, but with an insignificant magnetoelectric effect, were used. SKOV-3 ovarian cancer cells were then treated with the same nanoparticles, and viability was measured with an adenosine triphosphate (ATP) assay. These measurements show a decrease in cell viability up to 60.3% of control ( = 0.0052), which mirrored the efficacy of dye degradation of up to 69.8% ( = 0.0037) in each of the particle variants, demonstrating the value of azo dye degradation as a simple screening test for MENPs, and showing the potential of MENPs used as wirelessly controlled nanodevices to allow targeted electric field-based treatments.
在过去十年中,磁电纳米颗粒(MENPs)已被证明在响应磁场刺激时能够有效地产生局部电场。这类纳米颗粒的应用广泛多样,先前的研究实例包括用于按需药物释放、神经活动的无线调制和记录以及有机染料降解。本研究调查了将有机染料降解用作快速高效的筛选工具以检测MENPs磁电效应的潜力,以及这种测试结果如何反映所述纳米颗粒的抗增殖效应。选择台盼蓝作为一种偶氮染料来测试染料降解情况。将装有该染料的小瓶用具有不同特性的CoFe2O4@BaTiO3核壳型MENPs进行处理,同时有或没有1kHz 250Oe的磁刺激。使用紫外可见光谱法测量染料降解情况。染料降解效率随纳米颗粒合成参数的变化而变化。作为对照,使用了相同组成但磁电效应不显著的纳米颗粒。然后用相同的纳米颗粒处理SKOV - 3卵巢癌细胞,并通过三磷酸腺苷(ATP)测定法测量细胞活力。这些测量结果显示细胞活力下降至对照的60.3%(P = 0.0052),这反映了每个颗粒变体中高达69.8%(P = 0.0037)的染料降解效率,证明了偶氮染料降解作为MENPs简单筛选测试的价值,并显示了MENPs用作无线控制纳米器件以实现基于电场的靶向治疗的潜力。
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