Ozturk Esra Altay, Ege Zeynep Ruya, Murat Semiha, Erdemir Gokce, Kuruca Serap, Erkmen Ziya Engin, Duygulu Ozgur, Gunduz Oguzhan, Caykara Tuncer, Eroglu Mehmet S
Department of Chemistry, Faculty of Science, Gazi University, Besevler, 06500 Ankara, Turkey.
Department of Materials Science and Engineering, Technology Faculty, Marmara University, Aydınevler, Maltepe, 34854, Istanbul, Turkey; Center for Nanotechnology & Biomaterials Application and Research at Marmara University, Aydınevler, Maltepe, 34854 Istanbul, Turkey.
Int J Biol Macromol. 2022 Sep 30;217:562-571. doi: 10.1016/j.ijbiomac.2022.07.055. Epub 2022 Jul 15.
Two types of MgAl layered double hydroxide nanoparticles, MgAl LDH, at Mg:Al ratio of 2:1 and 3:1were prepared and used as inorganic fillers to improve the mechanical properties of poly(lactic acid)/poly(ethylene oxide) (PLA/PEO) electrospun composite fibers. Their detailed structural characterization was performed using X-ray diffraction (XRD) and transmission electron spectroscopy (TEM) techniques. Spectroscopic, thermal, mechanical, and morphological properties of the electrospun composite fibers, and cell proliferation on their surface, were examined. XRD and TEM analyses showed that the LDH nanoparticles were 50 nm in size and the Mg:Al ratio did not affect the average spacing between crystal layers. Fourier transform infrared (FTIR) and thermal analyses (TA) revealed the compatibility of the filler and the polymer matrix. The nanoparticles considerably improved the mechanical properties of the electrospun mats. The tensile strength and elongation at break values of the composite samples increased from 0.22 MPA to 0.40 MPa and 12.2 % to 45.66 %, respectively, resulting from the interaction between LDH and the polymer matrix. Scanning electron microscopy (SEM) and MTT analyses demonstrated that the electrospun composite fibers supported the SaOS-2 cells attachment and proliferation on the fiber surfaces, along with their suitable cytocompatibility.
制备了两种镁铝比分别为2:1和3:1的镁铝层状双氢氧化物纳米颗粒（MgAl LDH），并将其用作无机填料，以改善聚乳酸/聚环氧乙烷（PLA/PEO）电纺复合纤维的机械性能。使用X射线衍射（XRD）和透射电子光谱（TEM）技术对其进行了详细的结构表征。研究了电纺复合纤维的光谱、热、机械和形态学性能，以及细胞在其表面的增殖情况。XRD和TEM分析表明，LDH纳米颗粒尺寸为50 nm，镁铝比不影响晶体层之间的平均间距。傅里叶变换红外光谱（FTIR）和热分析（TA）揭示了填料与聚合物基体的相容性。纳米颗粒显著改善了电纺毡的机械性能。由于LDH与聚合物基体之间的相互作用，复合样品的拉伸强度和断裂伸长率值分别从0.22 MPa提高到0.40 MPa，从12.2%提高到45.66%。扫描电子显微镜（SEM）和MTT分析表明，电纺复合纤维支持SaOS-2细胞在纤维表面的附着和增殖，同时具有良好的细胞相容性。
