Musser J M, Bemis D A, Ishikawa H, Selander R K
J Bacteriol. 1987 Jun;169(6):2793-803. doi: 10.1128/jb.169.6.2793-2803.1987.
A total of 303 isolates of Bordetella bronchiseptica recovered from 11 host species were characterized by the electrophoretic mobilities of 15 metabolic enzymes, and 21 distinctive multilocus genotypes (electrophoretic types) were distinguished on the basis of allele profiles at the enzyme loci. The population structure of B. bronchiseptica is clonal, and its genetic diversity is limited in comparison with most other pathogenic bacteria, perhaps reflecting a relatively recent origin of the species. Electrophoretic types mark clones which are, in many cases, nonrandomly associated with host species. Clones differing only slightly in overall chromosomal genetic character may have pronounced differences in virulence potential. There was considerable variation among individual clones and clone families in degree of host specificity and among various species of hosts in the diversity of clones causing disease. The diversity of clones infecting dogs was an order of magnitude greater than that of clones infecting pigs. Most bordetellosis in pigs in the United States and Japan was found to be caused by strains of a single multilocus genotype.
从11种宿主物种中分离出的303株支气管败血波氏杆菌，通过15种代谢酶的电泳迁移率进行了特征分析，并根据酶基因座的等位基因谱区分出21种独特的多位点基因型（电泳类型）。支气管败血波氏杆菌的群体结构是克隆性的，与大多数其他病原菌相比，其遗传多样性有限，这可能反映了该物种相对较新的起源。电泳类型标记的克隆在许多情况下与宿主物种非随机相关。在整体染色体遗传特征上仅有轻微差异的克隆，其毒力潜力可能有显著差异。个体克隆和克隆家族在宿主特异性程度上存在相当大的差异，不同宿主物种中引起疾病的克隆多样性也存在差异。感染犬的克隆多样性比感染猪的克隆多样性高一个数量级。在美国和日本，发现猪的大多数博德特氏菌病是由单一多位点基因型的菌株引起的。
