父母的注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）症状，以及心理社会风险对极早产儿儿童注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）症状的影响。
Parental ADHD and ASD symptoms and contributions of psychosocial risk to childhood ADHD and ASD symptoms in children born very preterm.
机构信息
Medical Education, Washington University School of Medicine, St Louis, MO, USA.
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA.
出版信息
J Perinatol. 2023 Apr;43(4):458-464. doi: 10.1038/s41372-022-01463-w. Epub 2022 Jul 15.
OBJECTIVES
Examine maternal and paternal ADHD and ASD symptoms in relation to very preterm (VPT) and full-term (FT) children's ADHD and ASD symptoms.
STUDY DESIGN
In this longitudinal study, maternal- and teacher-report of child ADHD and ASD symptoms were obtained for 119 children (VPT = 79, FT = 40) at age 5-years using the Conner's Rating Scale-Revised (CRS-R) and Social Responsiveness Scale-2 (SRS-2). A biological parent completed self- and observer-report CRS-R and SRS-2, and measures of mood/affect, stress, and social support to assess psychosocial distress. Data were analyzed using mixed-effect models adjusted for covariates.
RESULTS
Child ADHD symptoms were associated with VPT birth, maternal distress, and maternal ADHD symptoms (p ≤ 0.02), and paternal ADHD symptoms (p < 0.001). Regarding ASD, VPT birth and parental ASD symptoms were associated with child ASD symptoms (p ≤ 0.009). Parental symptoms and birth group had no interaction.
CONCLUSIONS
VPT birth and parental psychopathology represent independent risks for ADHD and ASD.
目的
研究母体和父体注意缺陷多动障碍（ADHD）和自闭症谱系障碍（ASD）症状与极早产儿（VPT）和足月产（FT）儿童 ADHD 和 ASD 症状的关系。
研究设计
在这项纵向研究中，使用康纳氏评定量表修订版（CRS-R）和社会反应量表-2（SRS-2），在 5 岁时，对 119 名儿童（VPT=79，FT=40）的母亲和教师报告的儿童 ADHD 和 ASD 症状进行了评估。一位生物学上的父母完成了自我和观察报告的 CRS-R 和 SRS-2，以及情绪/情感、压力和社会支持的测量，以评估心理社会困扰。使用混合效应模型分析数据，并对协变量进行调整。
结果
儿童 ADHD 症状与 VPT 出生、母亲困扰和母亲 ADHD 症状（p≤0.02）以及父亲 ADHD 症状（p<0.001）相关。关于 ASD，VPT 出生和父母的 ASD 症状与儿童 ASD 症状相关（p≤0.009）。父母的症状和出生组之间没有相互作用。
结论
VPT 出生和父母的精神病理学是 ADHD 和 ASD 的独立风险因素。
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