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The minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing.

作者信息

Lei Xiao-Xuan, Cheng Liu Hang-Hang, Lin Hai-Yan, Yang Yu, Lu Yun-Yu, Pang Meng-Ru, Dong Yun-Qing, Bikker Floris J, Forouzanfar Tymour, Cheng Biao, Wu Gang

机构信息

Department of Oral and Maxillofacial Surgery/Pathology, Amsterdam UMC and Academic Center for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Amsterdam Movement Science, 1081HV, Amsterdam, The Netherlands.

Department of Burn and Plastic Surgery, General Hospital of Southern Theater Command, Liuhua Road 111, Guangzhou, 510030, China.

出版信息

Mil Med Res. 2022 Jul 16;9(1):41. doi: 10.1186/s40779-022-00398-9.

DOI:10.1186/s40779-022-00398-9
PMID:35841072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9287874/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e631/9287874/e01f8095984b/40779_2022_398_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e631/9287874/e01f8095984b/40779_2022_398_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e631/9287874/e01f8095984b/40779_2022_398_Fig1_HTML.jpg

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The minimal active domain of human salivary histatin 1 is efficacious in promoting acute skin wound healing.人唾液组蛋白1的最小活性结构域在促进急性皮肤伤口愈合方面有效。
Mil Med Res. 2022 Jul 16;9(1):41. doi: 10.1186/s40779-022-00398-9.
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Effects and mechanisms of histatins as novel skin wound-healing agents.Histatins 作为新型皮肤创伤愈合剂的作用和机制。
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Histatins, wound healing, and cell migration.Histatins，创伤愈合和细胞迁移。
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Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1,000-fold.组蛋白（一种来自人类唾液的强效伤口愈合肽）的构效分析：组蛋白环化使摩尔活性增强1000倍。
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The salivary peptide histatin-1 promotes endothelial cell adhesion, migration, and angiogenesis.唾液肽组蛋白-1可促进内皮细胞黏附、迁移和血管生成。
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Kinetics of histatin proteolysis in whole saliva and the effect on bioactive domains with metal-binding, antifungal, and wound-healing properties.全唾液中组蛋白的蛋白水解动力学及其对具有金属结合、抗真菌和伤口愈合特性的生物活性结构域的影响。
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Saliva and wound healing.唾液与伤口愈合。
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本文引用的文献

1
Human Salivary Histatin-1 Is More Efficacious in Promoting Acute Skin Wound Healing Than Acellular Dermal Matrix Paste.人唾液组蛋白-1在促进急性皮肤伤口愈合方面比无细胞真皮基质糊剂更有效。
Front Bioeng Biotechnol. 2020 Aug 19;8:999. doi: 10.3389/fbioe.2020.00999. eCollection 2020.
2
The Influence of Chronic Wound Extracts on Inflammatory Cytokine and Histatin Stability.慢性伤口提取物对炎性细胞因子和富组蛋白稳定性的影响。
PLoS One. 2016 Mar 28;11(3):e0152613. doi: 10.1371/journal.pone.0152613. eCollection 2016.
3
Structure-activity analysis of histatin, a potent wound healing peptide from human saliva: cyclization of histatin potentiates molar activity 1,000-fold.
鸡尾酒细胞重编程水凝胶微球实现无痕毛囊再生。
Adv Sci (Weinh). 2024 Mar;11(12):e2306305. doi: 10.1002/advs.202306305. Epub 2024 Jan 15.
组蛋白（一种来自人类唾液的强效伤口愈合肽）的构效分析：组蛋白环化使摩尔活性增强1000倍。
FASEB J. 2009 Nov;23(11):3928-35. doi: 10.1096/fj.09-137588. Epub 2009 Aug 3.
4
Large-scale manufacture of peptide therapeutics by chemical synthesis.通过化学合成大规模生产肽类治疗药物。
Nat Rev Drug Discov. 2003 Jul;2(7):587-93. doi: 10.1038/nrd1133.
5
Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.富组蛋白，人类腮腺分泌物中富含组氨酸的新型蛋白质家族。分离、特性、一级结构及对白色念珠菌的抑菌作用。
J Biol Chem. 1988 Jun 5;263(16):7472-7.