Amariglio Rebecca E, Buckley Rachel F, Mormino Elizabeth C, Marshall Gad A, Johnson Keith A, Rentz Dorene M, Sperling Reisa A
Center for Alzheimer Research and Treatment, Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Alzheimers Dement (N Y). 2018 Sep 6;4:444-449. doi: 10.1016/j.trci.2018.08.005. eCollection 2018.
To investigate whether baseline subjective cognitive complaints (SCCs) predict longitudinal decline on neuropsychological testing and whether SCC increases longitudinally, in the setting of high levels of amyloid burden.
Two hundred seventy-nine clinically normal older participants (mean age = 73.7 ± 6.1 years) from the Harvard Aging Brain Study, a cohort of community-dwelling individuals, were followed longitudinally (4.27 ± 1.35 years) with annual subjective memory questionnaires and neuropsychological assessment. C Pittsburgh compound-B positron emission tomography was used to measure cortical amyloid and to classify status (Aβ+/Aβ-) at baseline.
Higher baseline SCC predicted more rapid cognitive decline on neuropsychological measures among those with elevated amyloid (t = -2.18, < .0001). In addition, longitudinal report of SCC significantly increased over time, with SCC progression most pronounced among Aβ+ individuals (t = 2.24, = .0005).
SCC may inform risk for future cognitive decline and track progression of self-perceived decline, particularly in those along the AD trajectory, providing potentially important indicators of clinical meaningfulness in AD prevention trials.
在高淀粉样蛋白负荷的情况下，研究基线主观认知主诉（SCCs）是否能预测神经心理学测试中的纵向衰退，以及SCC是否会纵向增加。
来自哈佛衰老大脑研究（一组社区居住个体）的279名临床正常的老年参与者（平均年龄 = 73.7 ± 6.1岁），通过年度主观记忆问卷和神经心理学评估进行纵向随访（4.27 ± 1.35年）。使用C匹兹堡化合物B正电子发射断层扫描来测量皮质淀粉样蛋白并在基线时对状态（Aβ+/Aβ-）进行分类。
较高的基线SCC预测了淀粉样蛋白升高者在神经心理学测量上认知衰退更快（t = -2.18，< .0001）。此外，SCC的纵向报告随时间显著增加，SCC进展在Aβ+个体中最为明显（t = 2.24， = .0005）。
SCC可能为未来认知衰退的风险提供信息，并追踪自我感知衰退的进展，特别是在那些处于AD轨迹的人群中，为AD预防试验中具有临床意义的潜在重要指标提供依据。
