College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Laboratory management office, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Int J Biol Macromol. 2022 Sep 30;217:536-551. doi: 10.1016/j.ijbiomac.2022.07.070. Epub 2022 Jul 16.
Poria cocos polysaccharide (PCP) is one of the main active components of Poria cocos that is extensively used in the world. PCP can be divided into intro-polysaccharides and exopolysaccharides. PCP is mainly composed of glucose, galactose and mannose. There are many methods to exact PCP, and methods can affect its yield. PCP and its derivatives exhibit diverse biological functions such as antitumour, antioxidant, anti-inflammatory, immune-regulatory, hepatoprotective, etc. There is the potential application of PCP as drug carriers. The review provides a comprehensive summary of the latest extraction and purification methods of PCP, its chemistry, synthesis of PCP derivates, their pharmacological activities and their applications as drug carriers. This review provides comprehensive information on PCP, which can be used as the basis for further research on PCP and its derivates.
茯苓多糖（PCP）是茯苓中广泛应用于世界的主要活性成分之一。PCP 可分为内多糖和外多糖。PCP 主要由葡萄糖、半乳糖和甘露糖组成。有许多方法可以提取 PCP，方法会影响其产量。PCP 及其衍生物具有多种生物功能，如抗肿瘤、抗氧化、抗炎、免疫调节、保肝等。PCP 作为药物载体具有潜在的应用价值。综述了 PCP 的最新提取和纯化方法、其化学、PCP 衍生物的合成、它们的药理学活性及其作为药物载体的应用。该综述提供了关于 PCP 的全面信息，可作为进一步研究 PCP 及其衍生物的基础。
