Soman Anjana, Asha Nair S
Cancer Research Program 4, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India; Research Centre, University of Kerala, Thiruvananthapuram, India.
Cancer Research Program 4, Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, Kerala, India.
Biochim Biophys Acta Rev Cancer. 2022 Sep;1877(5):188760. doi: 10.1016/j.bbcan.2022.188760. Epub 2022 Jul 16.
SERine Protease INhibitor clade A member 3 (SERPINA3), a member of the SERine-Protease INhibitor (SERPIN) superfamily, principally works as a protease inhibitor in maintaining cellular homeostasis. It is a matricellular acute-phase glycoprotein that appears to be the sole nuclear-binding secretory serpin. Several studies have emerged in recent years demonstrating its link to cancer and disease biology. SERPINA3 seems to have cancer- and compartment-specific biological functions, acting either as a tumour promoter or suppressor in different cancers. However, the localization, mechanism of action and the effectors of SERPINA3 in physiological and pathological scenarios remain obscure. Our review aims to consolidate the current evidence of SERPINA3 in various cancers, highlighting its association with the cancer hallmarks and ratifying its status as an emerging cancer biomarker. The elucidation of SERPINA3-mediated cancer progression and its targeting might shed light on the realm of cancer therapeutics.
丝氨酸蛋白酶抑制剂A家族成员3（SERPINA3）是丝氨酸蛋白酶抑制剂（SERPIN）超家族的一员，主要作为蛋白酶抑制剂维持细胞稳态。它是一种基质细胞急性期糖蛋白，似乎是唯一具有核结合能力的分泌型丝氨酸蛋白酶抑制剂。近年来出现了几项研究，证明了它与癌症和疾病生物学的联系。SERPINA3似乎具有癌症和组织特异性的生物学功能，在不同癌症中既可以作为肿瘤促进剂，也可以作为肿瘤抑制剂。然而，SERPINA3在生理和病理情况下的定位、作用机制和效应分子仍不清楚。我们的综述旨在整合目前关于SERPINA3在各种癌症中的证据，强调其与癌症特征的关联，并认可其作为新兴癌症生物标志物的地位。对SERPINA3介导的癌症进展及其靶向作用的阐明可能会为癌症治疗领域带来启示。
