Moshage H J, Janssen J A, Franssen J H, Hafkenscheid J C, Yap S H
J Clin Invest. 1987 Jun;79(6):1635-41. doi: 10.1172/JCI113000.
Hypoalbuminemia in inflammatory disorders is not an infrequent finding. However, little is known about albumin synthesis in these patients. In the present study we have measured the albumin synthesis in four patients with inflammatory diseases using the [14C]carbonate technique. Because inflammation causes a decreased albumin synthesis and this decreased synthesis could not be related to a reduced amino acid supply, we have also examined the possible molecular mechanisms of reduced albumin synthesis during inflammation using in vivo and in vitro experiments in rats. In rats with turpentine-induced inflammation, serum albumin concentration and liver albumin mRNa level were markedly decreased. These changes could not be reproduced by administration of fibrinogen-, or fibrin-degradation products, or several hormones, such as corticosteroids, growth hormone, and adrenaline. However, monocytic products, especially interleukin 1, postulated to be important mediators of the inflammatory response, reduced albumin synthesis and liver albumin messenger RNA content but not total protein synthesis in rats in vivo and in primary cultures of rat hepatocytes. These findings suggest that monocytic products play an important role in reduced albumin synthesis during inflammation.
炎症性疾病中的低白蛋白血症并非罕见发现。然而，对于这些患者的白蛋白合成情况却知之甚少。在本研究中，我们使用[14C]碳酸盐技术测定了4例炎症性疾病患者的白蛋白合成。由于炎症导致白蛋白合成减少，且这种合成减少与氨基酸供应减少无关，我们还利用大鼠体内和体外实验研究了炎症期间白蛋白合成减少的可能分子机制。在松节油诱导炎症的大鼠中，血清白蛋白浓度和肝脏白蛋白mRNA水平显著降低。给予纤维蛋白原、纤维蛋白降解产物或几种激素（如皮质类固醇、生长激素和肾上腺素）并不能重现这些变化。然而，单核细胞产物，尤其是白细胞介素1，被认为是炎症反应的重要介质，在大鼠体内和大鼠原代肝细胞培养中可降低白蛋白合成和肝脏白蛋白信使RNA含量，但不影响总蛋白合成。这些发现表明，单核细胞产物在炎症期间白蛋白合成减少中起重要作用。
