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水飞蓟宾与辣椒素联合通过抑制NF-κB和MAPK激活增强对脂多糖诱导的RAW264.7细胞的抗炎作用

Enhanced Anti-Inflammatory Effects of Silibinin and Capsaicin Combination in Lipopolysaccharide-Induced RAW264.7 Cells by Inhibiting NF-κB and MAPK Activation.

作者信息

Zheng Yingying, Chen Jie, Wu Xiaozheng, Zhang Xin, Hu Chunmei, Kang Yu, Lin Jing, Li Jiamin, Huang Yuechang, Zhang Xingmin, Li Chen

机构信息

School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, China.

出版信息

Front Chem. 2022 Jun 30;10:934541. doi: 10.3389/fchem.2022.934541. eCollection 2022.

DOI:10.3389/fchem.2022.934541
PMID:35844639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9279934/
Abstract

Silibinin and capsaicin both are natural product molecules with diverse biological activities. In this article, we investigated the anti-inflammatory effects of silibinin combined with capsaicin in lipopolysaccharide (LPS)-induced RAW264.7 cells. The results showed that silibinin combined with capsaicin strongly inhibited LPS-induced nitric oxide (NO), tumor necrosis factor-α (TNF-α), Interleukin-6 (IL-6), and COX-2. Moreover, silibinin combined with capsaicin potently inhibited nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways. The results of the present study indicate that silibinin combined with capsaicin effectively inhibits inflammation.

摘要

水飞蓟宾和辣椒素都是具有多种生物活性的天然产物分子。在本文中，我们研究了水飞蓟宾与辣椒素联合使用对脂多糖（LPS）诱导的RAW264.7细胞的抗炎作用。结果表明，水飞蓟宾与辣椒素联合使用能强烈抑制LPS诱导的一氧化氮（NO）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和环氧化酶-2（COX-2）。此外，水飞蓟宾与辣椒素联合使用能有效抑制核因子-κB（NF-κB）和丝裂原活化蛋白激酶（MAPK）信号通路。本研究结果表明，水飞蓟宾与辣椒素联合使用能有效抑制炎症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/53aa0d26bc94/fchem-10-934541-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/59808b54c3af/fchem-10-934541-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/7e5d36e4a2b8/fchem-10-934541-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/96754e126d5d/fchem-10-934541-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/e5bfe17f7c68/fchem-10-934541-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/957393e1e753/fchem-10-934541-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/44034eba7d58/fchem-10-934541-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/711e27a0e8a3/fchem-10-934541-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/53aa0d26bc94/fchem-10-934541-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/59808b54c3af/fchem-10-934541-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/7e5d36e4a2b8/fchem-10-934541-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/96754e126d5d/fchem-10-934541-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/e5bfe17f7c68/fchem-10-934541-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/957393e1e753/fchem-10-934541-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/44034eba7d58/fchem-10-934541-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/711e27a0e8a3/fchem-10-934541-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e135/9279934/53aa0d26bc94/fchem-10-934541-g008.jpg

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