Zhao Yuqi, Zhou Yingyu, Gong Ting, Liu Zhiting, Yang Wanying, Xiong Yi, Xiao Dan, Cifuentes Alejandro, Ibáñez Elena, Lu Weihong
School of Medicine and Health, Harbin Institute of Technology, 92 Xidazhi Street, Nangang District, Harbin 150001, China.
Zhengzhou Research Institute, Harbin Institute of Technology, Zhengzhou, Henan 450000, China.
iScience. 2024 Oct 9;27(11):111109. doi: 10.1016/j.isci.2024.111109. eCollection 2024 Nov 15.
Inflammatory conditions are key mediators in the progression of various diseases. Silymarin, derived from seeds and fruits, has shown efficacy in treating a range of liver diseases. The expanding corpus of research on silymarin highlights its promising role in preventing and managing inflammatory conditions and autoimmune without adverse effects. This review discusses the absorption, metabolism, and anti-inflammatory mechanisms of silymarin, exploring its impact on the secretion of inflammatory factors, such as nuclear factor kappa B (NF-κB) pathway, mitogen-activated protein kinase (MAPK) pathway, and antioxidant pathway. We delve into its disease-modifying potential for clinical applications, thereby laying a theoretical foundation for further silymarin research and clinical studies.
炎症状态是多种疾病进展的关键介质。水飞蓟素来源于种子和果实，已显示出对一系列肝脏疾病的治疗效果。关于水飞蓟素不断扩大的研究表明，它在预防和管理炎症状态及自身免疫方面具有潜在作用且无不良反应。本综述讨论了水飞蓟素的吸收、代谢和抗炎机制，探讨其对炎症因子分泌的影响，如核因子κB（NF-κB）途径、丝裂原活化蛋白激酶（MAPK）途径和抗氧化途径。我们深入研究其在临床应用中的疾病改善潜力，从而为进一步的水飞蓟素研究和临床研究奠定理论基础。
