足月儿和早产儿尿液中三叶因子3（TFF3）的浓度

The Urinary Concentration of Trefoil Factor 3 (TFF3) in the Term and Preterm Neonates.

作者信息

Kamianowska Monika, Rybi-Szumińska Agnieszka, Kamianowska Aleksandra, Maciejczyk Mateusz, Sołomianko Katarzyna, Koput Alicja, Wasilewska Anna

机构信息

Department of Neonatology and Neonatal Intensive Care, Medical University of Bialystok, M. C. Sklodowskiej 24a Street, 15-276 Białystok, Poland.

Department of Pediatrics and Nephrology, Medical University of Bialystok, 15-269 Bialystok, Poland.

出版信息

J Clin Med. 2023 Jul 27;12(15):4936. doi: 10.3390/jcm12154936.

DOI:10.3390/jcm12154936

PMID:37568337

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10419516/

Abstract

BACKGROUND

Distinguishing between a pathologic state and renal development is important in neonatology. Because the assessment of serum creatinine in neonates is not reliable, better biomarkers are needed. Trefoil factor 3 (TFF3) is proposed as a biomarker of kidney injury. The study aimed to assess its urinary concentration in healthy term and stable preterm neonates.

MATERIAL AND METHODS

The study included 80 term and 20 preterm neonates born in the Department of Perinatology of the University Clinical Hospital in Bialystok. Urine was obtained from the term neonates on the 1st day of life and from the preterm neonates on the 1st, 8th, 15th and 22nd day of life. The urinary concentration of TFF3 was determined using a commercially available immunoassay and was normalized for the urinary creatinine concentration (cr.).

RESULTS

The values of TFF3/cr. were higher in the preterm than in the term neonates ( < 0.05) (median (Q1-Q3): 1486.85 (614.92-3559.18) and 317.29 (68.07-671.40) ng/mg cr.). They did not differ in the subsequent days of the preterm neonates' lives. The ROC curve for TFF3/cr. in the preterm and term neonates showed AUC = 0.751 (cut-off value = 1684.25 ng/mg cr.).

CONCLUSIONS

Prematurity is associated with higher urinary excretion of TFF3. Male gender is associated with an increased urinary TFF3 excretion in term neonates.

摘要

背景

在新生儿学中，区分病理状态和肾脏发育很重要。由于新生儿血清肌酐的评估不可靠，因此需要更好的生物标志物。三叶因子3（TFF3）被提议作为肾损伤的生物标志物。本研究旨在评估其在足月健康新生儿和稳定早产新生儿尿液中的浓度。

材料与方法

本研究纳入了比亚韦斯托克大学临床医院围产医学科出生的80例足月新生儿和20例早产新生儿。足月新生儿在出生第1天采集尿液，早产新生儿在出生第1、8、15和22天采集尿液。使用市售免疫测定法测定尿液中TFF3的浓度，并根据尿肌酐浓度（cr.）进行标准化。

结果

早产新生儿的TFF3/cr.值高于足月新生儿（<0.05）（中位数（Q1-Q3）：1486.85（614.92-3559.18）和317.29（68.07-671.40）ng/mg cr.）。在早产新生儿随后的生活中，这些值没有差异。早产和足月新生儿TFF3/cr.的ROC曲线显示AUC = 0.751（临界值 = 1684.25 ng/mg cr.）。