遗传性血管性水肿与甲状腺自身免疫
Hereditary angioedema and thyroid autoimmunity.
作者信息
Muhlemann M F, Macrae K D, Smith A M, Beck P, Hine I, Hegde U, Milford-Ward A, Carter G D, Wise P H, Cream J J
出版信息
J Clin Pathol. 1987 May;40(5):518-23. doi: 10.1136/jcp.40.5.518.
Abstract
Sera from 91 patients with hereditary angioedema were screened for thyroid antibodies. The results for the 77 patients more than 17 years old were compared with previously published data for the prevalence of thyroid disease in a large community (Whickham). Of the female patients with hereditary angioedema, the prevalence of thyroglobulin antibodies (TGA) was 14.0%, higher than the expected 3% (p less than 0.001). The prevalence of thyroid microsomal antibodies (TMA) was 20%, also higher than the expected 7.6% (p less than 0.01). The age distributions of the females in both groups differed: in the group with hereditary angioedema there was a greater proportion of younger patients which should have resulted in a lower prevalence of thyroid antibodies. Adjusting for related patients with hereditary angioedema, there was still an increased prevalence of TGA (p less than 0.01) and TMA (p less than 0.01).
摘要
对91例遗传性血管性水肿患者的血清进行甲状腺抗体筛查。将77例17岁以上患者的结果与先前发表的关于一个大型社区（威克姆）甲状腺疾病患病率的数据进行比较。在患有遗传性血管性水肿的女性患者中，甲状腺球蛋白抗体（TGA）的患病率为14.0%，高于预期的3%（p<0.001）。甲状腺微粒体抗体（TMA）的患病率为20%，也高于预期的7.6%（p<0.01）。两组女性的年龄分布不同：在遗传性血管性水肿组中，年轻患者的比例更大，这本应导致甲状腺抗体的患病率更低。对患有遗传性血管性水肿的相关患者进行校正后，TGA（p<0.01）和TMA（p<0.01）的患病率仍然增加。
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