沙特阿拉伯重症患者谵妄的时点患病率：一项多中心观察性研究。

Point prevalence of delirium among critically ill patients in Saudi Arabia: A multicenter observational study.

作者信息

Alqadheeb Nada S, Hashhoush Mai S, Alharthy Abdulrahman M, Mahmood Nasir Nasim, Alfardan Zahra A, Amin Rashid, Maghrabi Khalid A, Almaani Mohammed A, Alyamany Mahmoud S, Alenezi Farhan Zayed, Alruwaili Abdulrahman R, Alkhatib Kasim H, Rugaan Asia S, Eltatar Faisal S, Algethamy Haifa M, Abudayah Abdullah M, Ghabashi Alaa E, ElRakaiby Galal B, Alkatheeri Khalid F, Alarifi Mohammed I, Al Mubarak Yousef A, Ismail Nadia H, Alnajdi Israa H, Ahmed Mohammed Elrazi I, Alansari Mariam A, Alenazi Ahmed O, Almuslim Osama M

机构信息

Department of Pharmacy, King Fahad Specialist Hospital, Dammam, Saudi Arabia.

Department of Critical Care Medicine, King Saud Medical City, Riyadh, Saudi Arabia.

出版信息

Int J Crit Illn Inj Sci. 2022 Apr-Jun;12(2):70-76. doi: 10.4103/ijciis.ijciis_76_21. Epub 2022 Jun 24.

DOI:10.4103/ijciis.ijciis_76_21

PMID:35845124

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9285125/

Abstract

BACKGROUND

Delirium in critically ill patients is independently associated with poor clinical outcomes. There is a scarcity of published data on the prevalence of delirium among critically ill patients in Saudi Arabia. Therefore, we sought to determine, in a multicenter fashion, the prevalence of delirium in critically ill patients in Saudi Arabia and explore associated risk factors.

METHODS

A cross-sectional point prevalence study was conducted on January 28, 2020, at 14 intensive care units (ICUs) across 3 universities and 11 other tertiary care hospitals in Saudi Arabia. Delirium was screened once using the Intensive Care Delirium Screening Checklist. We excluded patients who were unable to participate in a valid delirium assessment, patients admitted with traumatic brain injury, and patients with documented dementia in their medical charts.

RESULTS

Of the 407 screened ICU patients, 233 patients were enrolled and 45.9% were diagnosed with delirium. The prevalence was higher in mechanically ventilated patients compared to patients not mechanically ventilated (57.5% vs. 33.6%; < 0.001). In a multivariate model, risk factors independently associated with delirium included age (adjusted odds ratio [AOR], 1.021; 95% confidence interval [CI], 1.01-1.04; = 0.008), mechanical ventilation (AOR, 2.39; 95% CI, 1.34-4.28; = 0.003), and higher severity of illness (AOR, 1.01; 95% CI, 1.001-1.021; = 0.026).

CONCLUSION

In our study, delirium remains a prevalent complication, with distinct risk factors. Further studies are necessary to investigate long-term outcomes of delirium in critically ill patients in Saudi Arabia.

摘要

背景

危重症患者的谵妄与不良临床结局独立相关。沙特阿拉伯关于危重症患者谵妄患病率的已发表数据匮乏。因此，我们试图以多中心方式确定沙特阿拉伯危重症患者谵妄的患病率，并探索相关危险因素。

方法

2020年1月28日，在沙特阿拉伯3所大学的14个重症监护病房（ICU）以及另外11家三级护理医院进行了一项横断面现患率研究。使用重症监护谵妄筛查清单对谵妄进行一次筛查。我们排除了无法参与有效谵妄评估的患者、因创伤性脑损伤入院的患者以及病历中有痴呆记录的患者。

结果

在407名接受筛查的ICU患者中，233名患者被纳入研究，45.9%被诊断为谵妄。与未接受机械通气的患者相比，接受机械通气的患者患病率更高（57.5%对33.6%；<0.001）。在多变量模型中，与谵妄独立相关的危险因素包括年龄（调整后的优势比[AOR]，1.021；95%置信区间[CI]，1.01 - 1.04； = 0.008）、机械通气（AOR，2.39；95%CI，1.34 - 4.28； = 0.003）以及更高的疾病严重程度（AOR，1.01；95%CI，1.001 - 1.021； = 0.026）。