Jing Fu-Yu, Wang Xiu-Ling, Song Jia-Li, Gao Yan, Cui Jian-Lan, Xu Wei, Yang Yang, Song Li-Juan, Zhang Hai-Bo, Lu Jia-Peng, Li Xi, Zheng Xin
National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing, China.
National Clinical Research Center for Cardiovascular Diseases, Shenzhen, Coronary Artery Disease Center, Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen, China.
J Geriatr Cardiol. 2022 Jun 28;19(6):418-427. doi: 10.11909/j.issn.1671-5411.2022.06.010.
Epidemiologic studies have explored the association between a single cardiovascular risk factor (CVRF) and resting heart rate (RHR), but the research on the relation of multiple risk factors with RHR remains scarce. This study aimed to explore the associations between CVRFs clustering and the risk of elevated RHR.
In this cross-sectional study, adults aged 35-75 years from 31 provinces were recruited by the China PEACE Million Persons Projects from September 2015 to August 2020. We focused on seven risk factors: hypertension, diabetes mellitus, dyslipidemia, obesity, smoking, alcohol use, and low physical activity. Multivariate logistic regression was used to calculate odds ratios (OR) for elevated RHR (> 80 beats/min).
Among 1,045,405 participants, the mean age was 55.67 ± 9.86 years, and 60.4% of participants were women. The OR (95% CI) for elevated RHR for the groups with 1, 2, 3, 4 and ≥ 5 risk factor were 1.11 (1.08-1.13), 1.36 (1.33-1.39), 1.68 (1.64-1.72), 2.01 (1.96-2.07) and 2.58 (2.50-2.67), respectively ( < 0.001). The association between the CVRFs clustering number and elevated RHR was much more pronounced in young males than in other age-sex subgroups. Clusters comprising more metabolic risk factors were associated with a higher risk of elevated RHR than those comprising more behavioral risk factors.
There was a significant positive association between the CVRFs clustering number and the risk of elevated RHR, particularly in young males. Compared clusters comprising more behavioral risk factors, clusters comprising more metabolic risk factors were associated with a higher risk of elevated RHR. RHR may serve as an indicator of the cumulative effect of multiple risk factors.
流行病学研究已探讨单一心血管危险因素（CVRF）与静息心率（RHR）之间的关联，但关于多种危险因素与RHR关系的研究仍然较少。本研究旨在探讨CVRF聚集与RHR升高风险之间的关联。
在这项横断面研究中，2015年9月至2020年8月期间，中国心脏调查万人项目从31个省份招募了35 - 75岁成年人。我们关注七个危险因素：高血压、糖尿病、血脂异常、肥胖、吸烟、饮酒和低体力活动。采用多因素logistic回归计算RHR升高（>80次/分钟）的比值比（OR）。
在1,045,405名参与者中，平均年龄为55.67±9.86岁，60.4%为女性。具有1、2、3、4和≥5个危险因素组的RHR升高的OR（95%CI）分别为1.11（1.08 - 1.13）、1.36（1.33 - 1.39）、1.68（1.64 - 1.72）、2.01（1.96 - 2.07）和2.58（2.50 - 2.67）（P<0.001）。CVRF聚集数量与RHR升高之间的关联在年轻男性中比在其他年龄 - 性别亚组中更为明显。包含更多代谢危险因素的聚集组比包含更多行为危险因素的聚集组与RHR升高风险更高相关。
CVRF聚集数量与RHR升高风险之间存在显著正相关，尤其是在年轻男性中。与包含更多行为危险因素的聚集组相比，包含更多代谢危险因素的聚集组与RHR升高风险更高相关。RHR可能作为多种危险因素累积效应的一个指标。
