Non-communicable Diseases Research Unit, South African Medical Research Council (SAMRC), Durban, 4001, South Africa.
Department of Medicine, University of Cape Town (UCT), Cape Town, 8001, South Africa.
Sci Rep. 2020 Mar 12;10(1):4605. doi: 10.1038/s41598-020-61502-4.
This study determined the associations of resting heart rate (RHR) with cardiovascular disease risk factors (CVDRF) in 25-74-year-old black South Africans. This cross-sectional study determined CVDRF by administered questionnaires, clinical measurements and biochemical analyses, including oral glucose tolerance tests. Multivariable linear regression models determined the associations of rising RHR with CVDRF. The basic model comprised age, gender, urbanisation, problematic alcohol use, daily cigarette smoking, physical activity and waist circumference. Glucose, blood pressure and cholesterol variables were entered separately and individually in the above model. Among the 1054 participants (382 men and 672 women, mean age 42.8 years), mean RHR was 70.6 beats per minute (bpm) and significantly higher in women (73.6 bpm) compared with men (65.3 bpm). RHR peaked in 45-54-year-old men (69.3 bpm) and 25-34-year-old women (75.3 bpm). Prevalence of RHR < 60 bpm and ≥90 bpm was 24.3% and 6.2%. In the regression model, female gender, problematic alcohol use, decreasing physical activity and increasing waist circumference were significantly associated with rising RHR. All glycaemic variables (diabetes, fasting glucose and 2-hour glucose) and diastolic blood pressure were significantly associated with RHR. The use of RHR in daily primary healthcare settings to identify increased risk for CVDRF should perhaps be encouraged.
本研究旨在确定南非黑人 25-74 岁人群静息心率（RHR）与心血管疾病风险因素（CVDRF）之间的相关性。该横断面研究通过问卷调查、临床测量和生化分析（包括口服葡萄糖耐量试验）确定 CVDRF。多变量线性回归模型确定了 RHR 升高与 CVDRF 的相关性。基本模型包括年龄、性别、城市化程度、酒精使用问题、每日吸烟、身体活动和腰围。血糖、血压和胆固醇变量分别单独并逐个输入上述模型。在 1054 名参与者（382 名男性和 672 名女性，平均年龄 42.8 岁）中，平均 RHR 为 70.6 次/分钟（bpm），女性（73.6 bpm）明显高于男性（65.3 bpm）。RHR 在 45-54 岁的男性（69.3 bpm）和 25-34 岁的女性（75.3 bpm）中达到峰值。RHR<60 bpm 和≥90 bpm 的患病率分别为 24.3%和 6.2%。在回归模型中，女性、酒精使用问题、体力活动减少和腰围增加与 RHR 升高显著相关。所有血糖变量（糖尿病、空腹血糖和 2 小时血糖）和舒张压与 RHR 显著相关。或许应该鼓励在日常初级保健环境中使用 RHR 来识别 CVDRF 的风险增加。
