可改变的痴呆风险因素对认知的不良影响在整个成年期会不断放大。
The adverse effect of modifiable dementia risk factors on cognition amplifies across the adult lifespan.
作者信息
LaPlume Annalise A, McKetton Larissa, Levine Brian, Troyer Angela K, Anderson Nicole D
机构信息
Rotman Research Institute Baycrest Health Sciences Toronto Canada.
Department of Psychology University of Toronto Toronto Canada.
出版信息
Alzheimers Dement (Amst). 2022 Jul 13;14(1):e12337. doi: 10.1002/dad2.12337. eCollection 2022.
BACKGROUND
Reversible lifestyle behaviors (modifiable risk factors) can reduce dementia risk by 40%, but their prevalence and association with cognition throughout the adult lifespan is less well understood.
METHODS
The associations between the number of modifiable risk factors for dementia (low education, hypertension, hearing loss, traumatic brain injury, alcohol or substance abuse, diabetes, smoking, and depression) and cognition were examined in an online sample ( = 22,117, ages 18-89).
FINDINGS
Older adults (ages 66-89) had more risk factors than middle-aged (ages 45-65) and younger adults (ages 18-44). Polynomial regression revealed that each additional risk factor was associated with lower cognitive performance (equivalent to 3 years of aging), with a larger association as age increased. People with no risk factors in their forties to seventies showed similar cognitive performance to people 10 or 20 years younger with many risk factors.
INTERPRETATION
Modifiable dementia risk factors amplify lifespan age differences in cognitive performance.
背景
可逆的生活方式行为（可改变的风险因素）可将痴呆风险降低40%，但其在整个成年期的患病率以及与认知的关联尚不清楚。
方法
在一个在线样本（n = 22117，年龄18 - 89岁）中，研究了痴呆可改变风险因素（低教育程度、高血压、听力损失、创伤性脑损伤、酒精或药物滥用、糖尿病、吸烟和抑郁）的数量与认知之间的关联。
研究结果
老年人（66 - 89岁）比中年人（45 - 65岁）和年轻人（18 - 44岁）有更多的风险因素。多项式回归显示，每增加一个风险因素与较低的认知表现相关（相当于3年的衰老），且随着年龄增长关联更大。在四五十岁到七十岁没有风险因素的人与有许多风险因素的年轻10岁或20岁的人表现出相似的认知能力。
解读
可改变的痴呆风险因素会扩大认知表现方面的寿命年龄差异。
Zotero 插件