单核苷酸多态性与地中海饮食对接受辅助激素治疗的超重或肥胖绝经后乳腺癌女性的影响：一项试点随机对照试验。

Effects of Single Nucleotide Polymorphisms and Mediterranean Diet in Overweight or Obese Postmenopausal Women With Breast Cancer Receiving Adjuvant Hormone Therapy: A Pilot Randomized Controlled Trial.

作者信息

Cho A-Ra, Hong Kyung-Won, Kwon Yu-Jin, Choi Ja-Eun, Lee Hye-Sun, Kim Hyung-Mi, Bae Soong June, Ahn Sung Gwe, Jeong Joon, Lee Ji-Won

机构信息

Chaum Life Center, CHA University, Seoul, South Korea.

Theragen Etex Bio Institute Co., Ltd., Suwon, South Korea.

出版信息

Front Nutr. 2022 Jul 1;9:882717. doi: 10.3389/fnut.2022.882717. eCollection 2022.

DOI:10.3389/fnut.2022.882717

PMID:35845810

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9284001/

Abstract

BACKGROUND AND AIMS

Weight management is recommended in overweight or obese breast cancer patients, as they have an increased risk of cancer recurrence and poor prognosis. Furthermore, identifying the relationships between genetic factors and nutrition could help suggest possible individualized nutritional solutions in weight management. The objective of this pilot randomized controlled trial was to investigate the influence of two obesity-associated single nucleotide polymorphisms and the Mediterranean diet intervention on weight loss and modification of nutrient intake and metabolic parameters in overweight or obese, postmenopausal, breast cancer patients receiving adjuvant hormone therapy.

METHODS

Seventy-eight breast cancer patients were randomly assigned to the Mediterranean diet (MeDiet) group or control group, and seventy-one were finally analyzed. Body composition, nutrient intake, and metabolic parameters were assessed at baseline and after the 8-week intervention. Fat mass and obesity-associated () rs7185735 and melanocortin-4 receptor () rs476828 variants were genotyped.

RESULTS

We found that both variants did not influence weight loss or improvement of metabolic parameters within the Mediterranean diet intervention. Intake of saturated fatty acid (SFA) and trans fat was significantly increased in C carriers compared with the TT genotype of rs476828 only in the control group ( = 0.002 for SFA; = 0.016 for trans fat), whereas no significant difference was observed between genotypes in the MeDiet group. There were statistically significant interactions between rs476828 and dietary intervention for changes in SFA intake ( = 0.009) and trans fat intake ( = 0.049).

CONCLUSION

Our data suggest that considering the effects of genotype may be more necessary when the Mediterranean diet is not followed and that this diet may have a protective role against the effects of certain genotypes. Further studies are required to determine the potential mechanism of the observed gene-diet interaction.

CLINICAL TRIAL REGISTRATION

[www.ClinicalTrials.gov], identifier [NCT04045392].

摘要

背景与目的

超重或肥胖的乳腺癌患者建议进行体重管理，因为他们癌症复发风险增加且预后较差。此外，确定遗传因素与营养之间的关系有助于在体重管理中提出可能的个性化营养解决方案。这项初步随机对照试验的目的是研究两种与肥胖相关的单核苷酸多态性以及地中海饮食干预对接受辅助激素治疗的超重或肥胖绝经后乳腺癌患者体重减轻、营养摄入改变和代谢参数的影响。

方法

78名乳腺癌患者被随机分配到地中海饮食（MeDiet）组或对照组，最终分析了71名患者。在基线和8周干预后评估身体成分、营养摄入和代谢参数。对脂肪量和肥胖相关的（）rs7185735和黑皮质素-4受体（）rs476828变体进行基因分型。

结果

我们发现，在地中海饮食干预中，这两种变体均未影响体重减轻或代谢参数的改善。仅在对照组中，与rs476828的TT基因型相比，C携带者的饱和脂肪酸（SFA）和反式脂肪摄入量显著增加（SFA为=0.002；反式脂肪为=0.016），而在地中海饮食组中各基因型之间未观察到显著差异。rs476828与饮食干预之间在SFA摄入量变化（=0.009）和反式脂肪摄入量变化（=0.049）方面存在统计学显著的相互作用。