Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), P.O. Box:14155-6117, Tehran, Iran.
BMC Endocr Disord. 2022 May 10;22(1):121. doi: 10.1186/s12902-022-01023-5.
Recent studies have shown that dietary carbohydrate quantity and quality as well as genetic variants may contribute to determining the metabolic rate and general and central obesity. This study aimed to examine interactions between melanocortin 4 receptor gene (MC4R) rs17782313 and dietary carbohydrate intake, glycemic index (GI), and glycemic load (GL) on body mass index (BMI), waist circumferences (WC), basal metabolic rate (BMR), and BMR/kg in overweight/obese women.
A total of 282 Iranian women (BMI ≥ 25) aged 18-56 years were enrolled in this cross-sectional study. All participants were assessed for blood parameters, body composition, BMR, and dietary intake. Dietary carbohydrate intake, GI, and GL were determined using a valid, reliable 147-item food frequency questionnaire. MC4R rs17782313 was genotyped by the restriction fragment length polymorphism (PCR-RFLP) method.
After adjustment for age and energy intake, significant interactions were observed between carbohydrate intake and MC4R rs17782313 in terms of BMI (P Interaction = 0.007), WC (P Interaction = 0.02), and BMR/kg (P Interaction = 0.003) in this way that higher carbohydrate intake, compared with lower intake, was associated with an increase in BMI and WC for individuals with C allele carriers (TC + CC genotypes), while related to an increase in BMR/kg for those carrying the TT genotype. No significant interaction was found between MC4R rs17782313 and GI and GL on BMI, WC, BMR/kg, and BMR.
Interactions between the MC4R rs17782313 and carbohydrate intake probably can have an effect on BMI, WC, and BMR/kg in overweight/obese women.
最近的研究表明，饮食碳水化合物的数量和质量以及遗传变异可能有助于确定代谢率以及全身和中心性肥胖。本研究旨在研究黑皮质素 4 受体基因（MC4R）rs17782313 与饮食碳水化合物摄入量、血糖指数（GI）和血糖负荷（GL）之间的相互作用对超重/肥胖女性的体重指数（BMI）、腰围（WC）、基础代谢率（BMR）和 BMR/kg 的影响。
本横断面研究共纳入 282 名伊朗女性（BMI≥25），年龄 18-56 岁。所有参与者均进行了血液参数、身体成分、BMR 和饮食摄入评估。饮食碳水化合物摄入量、GI 和 GL 采用经过验证的、可靠的 147 项食物频率问卷进行评估。MC4R rs17782313 通过限制性片段长度多态性（PCR-RFLP）方法进行基因分型。
在校正年龄和能量摄入后，碳水化合物摄入量与 MC4R rs17782313 之间存在显著的交互作用，表现在 BMI（P 交互=0.007）、WC（P 交互=0.02）和 BMR/kg（P 交互=0.003）方面，即与低摄入量相比，高碳水化合物摄入量与 C 等位基因携带者（TC+CC 基因型）的 BMI 和 WC 增加相关，而与 TT 基因型携带者的 BMR/kg 增加相关。MC4R rs17782313 与 GI 和 GL 之间不存在 BMI、WC、BMR/kg 和 BMR 的交互作用。
MC4R rs17782313 与碳水化合物摄入之间的相互作用可能对超重/肥胖女性的 BMI、WC 和 BMR/kg 有影响。
