Chany C, Pauloin A, Chany-Fournier F
Tex Rep Biol Med. 1977;35:330-5.
The model of the interferon receptor system initially proposed in 1973 is now supported by many independent observations and can be described with somewhat more precision. The cell membrane-bound receptor system consists of a nonspecific binding site made up of gangliosides (such as GM2). The activator site is probably formed by glycoproteins. It is likely that interferon has to interact with both sites at the surface of the cell membrane. The activator site carries probably the interferon species specific properties of the receptor, while all the other metabolic steps necessary for the development of antiviral activity are not species specific. The cooperation (resulting most likely in small aggregates) will change the conformational state of the membrane in a way compatible with the action of interferon. We postulate that many other cellular effects of interferon, such as priming, modification of antigenic properties, changes in membrane permeability, increase or decrease in sensitivity to toxins, repression of cellular DNA synthesis could be secondary effects related to cell membrane modulation. Experiments are now in progress to prove or disprove these postulates.
1973年最初提出的干扰素受体系统模型，如今得到了许多独立观察结果的支持，并且可以更精确地加以描述。细胞膜结合受体系统由一个由神经节苷脂（如GM2）构成的非特异性结合位点组成。激活位点可能由糖蛋白形成。干扰素可能必须与细胞膜表面的这两个位点相互作用。激活位点可能具有受体的干扰素种属特异性特性，而抗病毒活性发挥所需的所有其他代谢步骤则不具有种属特异性。这种协同作用（很可能导致形成小聚集体）将以与干扰素作用相适应的方式改变膜的构象状态。我们推测，干扰素的许多其他细胞效应，如启动作用、抗原特性的改变、膜通透性的变化、对毒素敏感性的增加或降低、细胞DNA合成的抑制，可能是与细胞膜调节相关的次级效应。目前正在进行实验以证实或反驳这些推测。
